35512-29-9

Usage

Uses

Used in Pharmaceutical Synthesis:
4-(4-Chlorophenyl)-1H-imidazole is utilized as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Pesticide Production:
In the agricultural industry, 4-(4-Chlorophenyl)-1H-imidazole is employed as a component in the production of certain pesticides. Its chemical properties make it suitable for use in creating compounds that can effectively control pests and protect crops.
Used in Organic Synthesis:
4-(4-Chlorophenyl)-1H-imidazole is also used as a building block in the synthesis of other organic compounds. Its reactivity and structural features enable it to be a valuable precursor in the creation of a wide range of chemical products.
Used in Research and Development:
Due to its potential biological and pharmacological properties, 4-(4-Chlorophenyl)-1H-imidazole is used in research and development to explore its applications in medicine and other fields. Scientists are interested in its possible effects on various biological systems and its potential to contribute to the development of new treatments and therapies.
Used in Antimicrobial and Antifungal Applications:
4-(4-Chlorophenyl)-1H-imidazole may possess antimicrobial and antifungal properties, making it a potential candidate for the development of new medical treatments. Its ability to inhibit the growth of certain microorganisms could lead to the creation of novel antibiotics or antifungal agents.
It is crucial to handle and use 4-(4-Chlorophenyl)-1H-imidazole with care, considering its potential health hazards and environmental impact. Proper safety measures should be taken to minimize risks associated with its use.

Upstream product

• 5467-71-0 4-chlorophenacylamine hydrochloride 
• 873-73-4 4-n-chlorophenylacetylene 
• 89108-47-4 4-diazo-4H-imidazole 
• 108-90-7 chlorobenzene 
• 2302-25-2 4-bromo-1 H-imidazole 
• 1679-18-1 4-Chlorophenylboronic acid 
• 93103-18-5 4-(4-chloro-phenyl)-1,3-dihydro-imidazole-2-thione 
• 77287-34-4 formamide 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 50-00-0 formaldehyd 
• 27993-56-2 1-(4-chlorophenyl)-2-hydroxyethanone 

Relevant academic research and scientific papers

Enantioselective γ-Addition of Pyrazole and Imidazole Heterocycles to Allenoates Catalyzed by Chiral Phosphine

Chiral phosphines were found to catalyze the enantioselective asymmetric γ-addition of heteroaromatic compounds to allenoates in good yields with high enantiomeric ratios and regioselectivity in the presence of (S)-BINOL. Both pyrazole and imidazole could

Preparation of Imidazole Derivatives via Bisfunctionalization of Alkynes Catalyzed by Ruthenium Carbonyl

A one-step, oxidative bisfunctionalization of alkynes to generate cis -enediol diacetates catalyzed by ruthenium carbonyl (triruthenium dodecacarbonyl) is presented. The reaction was performed using the alkyne, (diacetoxyiodo)benzene, Ru 3 (CO) 12 as the catalyst, and toluene as the solvent at 100 °C to give the cis -enediol diacetates in up to 82percent yields. This method overcomes the shortcomings of existing methods, such as tedious reaction steps, substrate limitations, and the use of toxic reagents. Furthermore, the reaction of module cis -enediol diacetates with ammonium carbonate [(NH 4) 2 CO 3 ] in an alcohol solvent gave imidazole derivatives in 37-84percent yields, thus providing a simple and mild new method for the synthesis of imidazole compounds.

One-pot synthesis of 2-alkyl-4(5)-aryl-1H-imidazoles from 1-aryl-2-bromoethanones, ammonium carbonate and aliphatic carboxylic acids

A simple and efficient protocol for the preparation of 2-alkyl-4(5)-aryl- 1H-imidazoles starting from α-bromo aryl methyl ketones and aliphatic carboxylic acids in the presence of ammonium carbonate has been developed.

Efficient and practical synthesis of 4(5)-aryl-1H-imidazoles and 2,4(5)-diaryl-1H-imidazoles via highly selective palladium-catalyzed arylation reactions

(Chemical Equation Presented) 4(5)-Aryl-1H-imidazoles can be efficiently and selectively prepared by PdCl2(dppf)-catalyzed Suzuki-Miyaura reaction of commercially available 4(5)-bromo-1H-imidazole with arylboronic acids under phase-transfer conditions. On the other hand, N-unprotected 4(5)-aryl-1H-imidazoles can undergo highly selective Pd(OAc)2- catalyzed and CuI-mediated direct C-2-arylation with a variety of aryl bromides and iodides under base-free and ligandless conditions to produce 2,4(5)-diaryl-1H-imidazoles in modest to good yields. No N-arylation byproducts are observed under the experimental conditions used to prepare 2,4(5)-diaryl-1H-imidazoles.

Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists

An imidazolylpyrimidine was identified in a CXCR2 chemokine receptor antagonist screen and was optimized for potency, in vitro metabolic stability, and oral bioavailability. It was found that subtle structural modification within the series affected the o

CARBENIC REACTIONS OF 4-DIAZO-4H-IMIDAZOLE WITH BENZENE DERIVATIVES

The electrophilic behavior of 4H-imidazolylidene is greatly modified by coordinating groups in benzene derivatives undergoing substitution.