355120-40-0

Basic information

• Product Name: 2,2'-[(THIOXOMETHYLENE)DISULFANYL]BIS(2-METHYLPROPANOIC ACID)
• Synonyms: 2,2'-[(THIOXOMETHYLENE)DISULFANYL]BIS(2-METHYLPROPANOIC ACID);2,2'-[Carbonothioylbis(thio)]bis[2-methylpropanoicacid],min.97%;2,2'-[Carbonothioylbis(thio)]bis[2-Methylpropanoic acid],97%;2,2'-[Carbonothioylbis(thio)]bis[2-methylpropanoic acid];Propanoic acid, 2,2'-[carbonothioylbis(thio)]bis[2-methyl-
• CAS NO: 355120-40-0
• Molecular Formula: C₉H₁₄O₄S₃
• Molecular Weight: 282.40
• Mol File: 355120-40-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 178℃
• Appearance: /
• CAS DataBase Reference: 2,2'-[(THIOXOMETHYLENE)DISULFANYL]BIS(2-METHYLPROPANOIC ACID)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-[(THIOXOMETHYLENE)DISULFANYL]BIS(2-METHYLPROPANOIC ACID)(355120-40-0)
• EPA Substance Registry System: 2,2'-[(THIOXOMETHYLENE)DISULFANYL]BIS(2-METHYLPROPANOIC ACID)(355120-40-0)

Safety Data

• Hazardous Substances Data: 355120-40-0(Hazardous Substances Data)

Usage

General Description

The chemical 2,2'-[(thioxomethylene)disulfanyl]bis(2-methylpropanoic acid) is a compound with the molecular formula C11H16O4S2. It is a derivative of 2-methylpropanoic acid that contains a thioxomethylene disulfide group. 2,2'-[(THIOXOMETHYLENE)DISULFANYL]BIS(2-METHYLPROPANOIC ACID) is used in organic synthesis and pharmaceutical research due to its potential as a building block for creating new molecules and drugs. It is important to handle this chemical with caution, as it may have irritant or hazardous properties.

Upstream product

• 75-15-0 carbon disulfide 
• 67-66-3 chloroform 
• 67-64-1 acetone 

Downstream Products

• 1421706-02-6 bis(6-(4-(phenyldiazenyl)phenoxy)hexyl)-2,2′-(thiocarbonylbis(sulfanediyl))bis(2-methylpropanoate) 

Relevant articles and documents

Synthesis of magnetic polystyrene nanoparticles using amphiphilic ionic liquid stabilized RAFT mediated miniemulsion polymerization

Imidazole based amphiphilic ionic liquids (ILs) were used as surfactants in miniemulsion polymerization (MEP) of styrene using a free radical process as well as reversible addition-fragmentation chain transfer (RAFT). Monodisperse polystyrene (PS) nanoparticles were obtained, demonstrating the efficiency of the amphiphilic IL as surfactant in MEP. IL stabilized miniemulsion was furthermore used to prepare polystyrene based magnetic nanoparticles (MNP). A large increase of the possible MNP content associated with very good colloidal stability was achieved using IL stabilized RAFT mediated MEP where a carboxyl functionalized chain transfer agent (CTA) was applied, allowing interaction with the MNP surface. The molecular weight and dispersity index of polystyrene, the content of MNP, and the morphologies of the hybrid nanoparticles were controlled by proper optimization of the concentration of initiator and CTA. The materials have been analyzed by NMR, GPC, DLS, SEM, TEM, and TGA. Finally, the magnetic properties of the materials were determined by vibrating sample magnetometer (VSM) analysis.

Poly(N-isopropylacrylamide) hydrogels fabricated via click chemistry: Well-defined α,ω-bis propargyl linear poly(N-isopropylacrylamide)s as crosslinkers

A series of poly(N-isopropylacrylamide) (PNIPA) hydrogels were fabricated through click chemistry by using a well-defined azido-PNIPA carrying pendant azido groups, and linear α,ω-bis propargyl PNIPAs with different chain lengths. Here linear α,ω-bis propargyl PNIPAs were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization by using a bis propargyl terminal chain transfer agent, whose chain lengths were modulated by changing polymerization conditions. The obtained hydrogels showed increasing ESR values in the swollen state and increasing volume phase transition temperatures (VPTTs) with increasing molecular weights of bis propargyl PNIPAs, ascribed to the lengthening distance between crosslinks and improving hydrophilicity. The incorporation of amine together with crosslinking modified the hydrophilicity of a click hydrogel, resulting in the elevated VPTT and additional pH sensitivity. The present study provided a facile method to regulate swelling properties and/or to impart special functions for PNIPA hydrogels, by adjusting the chain length of crosslinkers or by introducing other functional groups. This journal is

End group polarity and block symmetry effects on cloud point and hydrodynamic diameter of thermoresponsive block copolymers

Thermoresponsive block copolymers are of interest for delivery vehicles in the body. Often an interior domain is designed for the active agent and the exterior domain provides stability in the bloodstream, and may carry a targeting ligand. There is still much to learn about how block sequence and chain end identity affect micelle structure, size, and cloud points. Here, hydrophilic oligo(ethylene glycol) methyl ether acrylate and more hydrophobic di(ethylene glycol) methyl ether methacrylate monomers were polymerized to give amphiphilic block copolymers with amphiphilic chain ends. The block sequence and chain end identity were both controlled by appropriate choice of RAFT chain transfer agents to study the effect of 'matched' and 'mismatched' chain end polarity with amphiphilic block sequence. The affect of matching or mismatching chain end polarity and block sequence was studied on the hydrodynamic diameter, cloud point, and temperature range of the chain collapse on linear di- and triblock copolymers and star diblock polymers. The affects of matching or mismatching chain end polarity were significant with linear diblock copolymers but more complex with triblock and star copolymers. Explanations of these results may help guide others in designing thermoresponsive block copolymers.