35519-07-4Relevant academic research and scientific papers
Synthesis and evaluation of new 4(3H)-Quinazolinone derivatives as potential anticancer agents
Gatadi, Srikanth,Pulivendala, Gauthami,Gour, Jitendra,Malasala, Satyaveni,Bujji, Sushmitha,Parupalli, Ramulu,Shaikh, Mujahid,Godugu, Chandraiah,Nanduri, Srinivas
, (2019/09/30)
A series of new 4(3H)-quinazolinones were synthesized and evaluated for their cytotoxic activity against a set of human cancer cell lines MDA-MB-231 and MCF-7 (breast), HCT-116 and HT-29 (colon) and A549 (lung). Among the tested compounds, 22a exhibited p
Synthesis and antitumor evaluation of some 1,3,4-oxadiazole-2(3H)-thione and 1,2,4-triazole-5(1H)-thione derivatives
Feng, Cheng Tao,Wang, Ling Dong,Yan, Yu Gang,Liu, Jian,Li, Shao Hua
experimental part, p. 315 - 320 (2012/09/07)
A series of 1,3,4-oxadiazole-2-thione and 1,2,4-triazole-5-thione derivatives have been successfully synthesized and studied for their antitumor activity. These compounds were prepared from carboxylic acids and chiral aminoacid esters. The prepared compounds were evaluated for their cytotoxicity against cancer in vitro using hydroxyurea (HU) as positive control. A fair number of compounds were found to have significant antitumor activity. To study the molecular basis of interaction and affinity of binding of the target molecules, all the compounds were docked into the ATPase domain of TP-II and tubulin using Schroedinger. Springer Science+Business Media, LLC 2010.
The effect of substituents on the chiral solvating properties of (S)-1,6-dialkylpiperazine-2,5-diones
Malavasic, Crt,Stanovnik, Branko,Wagger, Jernej,Svete, Jurij
experimental part, p. 1364 - 1371 (2011/11/29)
The effect of substituents on the chiral solvating properties of 13 different (S)-1,6-dialkylpiperazine-2,5-diones (S)-1a-m and five (3S,6S)-1,3,6-trialkyl analogues (S,S)-1n-r was studied by NMR in CDCl 3 with methyl (RS)-N-benzoylleucinate (R
Substituent effect on acidity of substituted 2-(4-nitrobenzoylamino)alkanamidesin methanol-dimethyl sulfoxide mixtures
Mitas, Petr,Sedlak, Milos,Kavalek, Jaromir
, p. 85 - 93 (2007/10/03)
The dissociation constants of substituted 2-(4-nitrobenzoylamino)alkanamides, N-[2-(4-nitrobenzoylamino)aikanoyl]pyrrolidines, and N-alkyl-4-nitrobenzamides have been measured spectrophotometrically in 60 and 80% v/v DMSO. The pKA values of these N-acids are discussed from the point of view of substituents at the acetamide a-carbon atom.
