5619-05-6

Basic information

• Product Name: DL-VALINE METHYL ESTER HYDROCHLORIDE
• Synonyms: TIMTEC-BB SBB003876;METHYL DL-VALINATE HYDROCHLORIDE;METHYL-2-AMINO-3-METHYL-BUTANOATE HCL;METHYL 2-AMINO-3-METHYLBUTANOATE HYDROCHLORIDE;H-DL-VAL-OME HCL;DL-VALINE METHYL ESTER HYDROCHLORIDE;DL-A-AMINOISOVALERIC ACID METHYL ESTER HYDROCHLORIDE;DL-2-AMINO-3-METHYLBUTANOIC ACID METHYL ESTER HYDROCHLORIDE
• CAS NO: 5619-05-6
• Molecular Formula: C₆H₁₄NO₂*Cl
• Molecular Weight: 167.63
• EINECS: 228-620-9
• Product Categories: Amino Acids Derivatives;Valine [Val, V];Amino Acids and Derivatives;Amino hydrochloride
• Mol File: 5619-05-6.mol

Chemical Properties

• Melting Point: 171 °C
• Boiling Point: 145.7 °C at 760 mmHg
• Flash Point: 20.7 °C
• Appearance: /
• Vapor Pressure: 4.8mmHg at 25°C
• Storage Temp.: −20°C
• Water Solubility: Soluble in water
• BRN: 3912090
• CAS DataBase Reference: DL-VALINE METHYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-VALINE METHYL ESTER HYDROCHLORIDE(5619-05-6)
• EPA Substance Registry System: DL-VALINE METHYL ESTER HYDROCHLORIDE(5619-05-6)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 5619-05-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
DL-VALINE METHYL ESTER HYDROCHLORIDE is used as an intermediate in the synthesis of tetrahydrobenzodiazepinones, which possess anti-HIV activities. These compounds are being developed as potential treatments for HIV/AIDS, offering new therapeutic options for patients in need.
Additionally, DL-VALINE METHYL ESTER HYDROCHLORIDE is used as a precursor in the synthesis of [(acylamino)methyl]lambertianic acid derivatives. These compounds have demonstrated antitumor activities, making them promising candidates for the development of cancer treatments. The use of DL-VALINE METHYL ESTER HYDROCHLORIDE in the production of these compounds contributes to the advancement of oncology research and the search for novel cancer therapies.

InChI:InChI=1/C6H13NO2.ClH/c1-4(2)5(7)6(8)9-3;/h4-5H,7H2,1-3H3;1H

Upstream product

• 67-56-1 methanol 
• 516-06-3 D,L-valine 
• 112792-74-2 trans-dichlorobis(2-imino-3-methylbutane acid-methylester)palladium 
• 95419-46-8 [PtCl₂(S(CH₃)2)(NH₂CH(COOCH₃)CH(CH₃)2)] 
• 618-36-0 rac-methylbenzylamine 
• 40216-62-4 N-benzyl-L-valine methyl ester 
• 4070-48-8 L-Valine methyl ester 

Downstream Products

• 114877-91-7 2-isothiocyanato-3-methyl-butyric acid methyl ester 
• 20613-35-8 DL-2-(2-Benzylthioethylamino)-3-methyl-butanol-⁽¹⁾ 
• 127750-57-6 (R,S)-methyl 3-methyl-2-{[(2E)-3-phenylprop-2-enoyl]amino}butanoate 
• 140151-66-2 methyl N-<<3-<(diethoxyphosphinyl)methyl>phenyl>methyl>-DL-valinate 
• 13803-83-3 methyl 2-(benzylideneamino)-3-methylbutanoate 
• 70304-35-7 2-(Methoxycarbonylamino)isovaleriansaeure-methylester 
• 4840-30-6 Z-Leu-Val-OMe 
• 323196-10-7 N-(N-benzyl-N-phenylfluorenyl-(S)-2-amino-4-pentenoyl)-(S)-valine methyl ester 
• 4070-48-8 D-Valine methyl ester 
• 4070-48-8 L-Valine methyl ester 
• 1492-13-3 (2R)-2-(benzoylamino)-3-methylbutyric acid methyl ester 
• 1492-13-3 N-benzoyl-L-valine methyl ester 
• 14599-03-2 methyl 2-benzamido-3-methylbutanoate 

Relevant articles and documents

Ferrocene-modified amino acids: synthesis and in vivo bioeffects on hippocampus

A method for the ferrocene modification of amino acids of natural and synthetic origin has been developed. In the in vivo studies, the hippocampal electrical activity under the action of ferrocenyl(phenylpyrazolyl)glycine (1) was assessed. A meaningful rise (up to 25% compared to the control) in the response amplitudes of the focal potentials of the hippocampal region СА1 after intraperitoneal administration of compound 1 at the dose of 2.0 mg kg–1 was established.

Regiodivergent Enantioselective γ-Additions of Oxazolones to 2,3-Butadienoates Catalyzed by Phosphines: Synthesis of α,α-Disubstituted α-Amino Acids and N,O-Acetal Derivatives

Phosphine-catalyzed regiodivergent enantioselective C-2- and C-4-selective γ-additions of oxazolones to 2,3-butadienoates have been developed. The C-4-selective γ-addition of oxazolones occurred in a highly enantioselective manner when 2-aryl-4-alkyloxazol-5-(4H)-ones were employed as pronucleophiles. With the employment of 2-alkyl-4-aryloxazol-5-(4H)-ones as the donor, C-2-selective γ-addition of oxazolones took place in a highly enantioselective manner. The C-4-selective adducts provided rapid access to optically enriched α,α-disubstituted α-amino acid derivatives, and the C-2-selective products led to facile synthesis of chiral N,O-acetals and γ-lactols. Theoretical studies via DFT calculations suggested that the origin of the observed regioselectivity was due to the distortion energy that resulted from the interaction between the nucleophilic oxazolide and the electrophilic phosphonium intermediate.

Selective oxidation of amines to aldehydes or imines using laccase-mediated bio-oxidation

An efficient and practical chemo-enzymatic aerobic oxidation in water of benzylamines to obtain aldehydes or imines is described. Laccase from Trametes versicolor was chosen as biocatalyst, and TEMPO (radical 2,2,6,6-tetramethylpiperidine 1-oxyl) as mediator. A study on the pH dependence of the aqueous medium allowed us to realise a fine tuning on product selectivity. Under our optimized reaction conditions, the bio-oxidation of a series of primary, secondary and cyclic amines has been achieved.

C-5′-substituted cinchona alkaloid derivatives catalyse the first highly enantioselective dynamic kinetic resolutions of azlactones by thiolysis

The highly enantioselective dynamic kinetic resolution (DKR) of azlactones by thiolysis has been achieved for the first time. Although both the parent alkaloid quinine and known C-5′-urea derivatives fail to promote the reaction effectively, a new class of C-5′-hydroxylated catalysts proved capable of catalysing the DKR of a range of azlactones derived from both unbranched- and, previously challenging, branched-chain amino acids in 84-92 % ee, including an example of the synthesis of an enantioenriched N-protected thioester derived from an extraterrestrial amino acid isolated from the Murchison meteorite. The highly enantioselective dynamic kinetic resolution (DKR) of azlactones by thiolysis has been achieved for the first time. Although both the parent alkaloid quinine and known C-5′-urea derivatives fail to promote the reaction effectively, a new class of C-5′-hydroxylated catalysts proved capable of catalysing the DKR of a range of azlactones in 84-92 % ee. Copyright

Highly tunable arylated cinchona alkaloids as bifunctional catalysts

We report the design and evaluation of a library of chiral bifunctional organocatalysts in which the distance between the catalytically active units can be systematically varied.

Antimicrobial toxicity studies of ionic liquids leading to a 'hit' MRSA selective antibacterial imidazolium salt

Imidazolium salts can be classed as surfactants, detergents, ionic liquids, reagents, catalysts or solvents. A study of the toxicity and ecotoxicity of these salts yields valuable information for their use as pharmaceuticals as well as impact on the environment. Our approach to screen a series of chiral imidazolium salts for toxicity to bacteria and fungi, including clinical pathogen strains, has led to the identification of a 'hit' MRSA selective antimicrobial compound. Preliminary structure-activity-relationship (SAR) information (required position of l-phenylalanine and l-valine group) is also elucidated within this first generation of compounds. Conversely, most of the imidazolium salts were nontoxic (IC95 > 2 mM) to the 12 fungi strains and 8 bacteria strains screened, and we propose that they are suitable candidates for 'green chemistry' applications. Ecotoxicity studies (Biodegradation ISO 14593 'CO2 Headspace Test') of two bromide ionic liquids containing l-phenylalanine residues indicate that these ionic liquids passed the test (>60% in 28 days) and classed as readily biodegradable.

Use of diphenyliodonium bromide in the synthesis of some N-phenyl-amino acids

The N-phenyl methyl esters 4 of glycine, alanine, valine, leucine, isoleucine, phenylalanine, methionine, proline, serine, threonine, tyrosine, aspartic acid, and glutamic acid have been synthesized in good to excellent yields using diphenyliodonium bromide, AgNO3, and a catalytic amount of CuBr starting from the relevant amino acid ester. The chiral integrity of the amino acids 5 was maintained during these reactions, which were confirmed by the synthesis of dipeptide for each N-phenyl amino acid. The structures of the new compounds were confirmed by the analysis of their IR, 1H, and 13C NMR spectra in addition to CHN microanalysis or high-resolution mass spectrometry for the new N-phenyl amino acids 5 and the esters 4.

Design and synthesis of N-methylmaleimide indolocarbazole bearing modified 2-acetamino acid moieties as Topoisomerase I inhibitors

A novel series of N-methylmaleimide indolocarbazole derivatives bearing modified 2-acetamino acid moieties are first reported. The cytotoxic effects of these compounds were tested in five human tumor cell lines. The potent compounds 9a, 9b, 9d, and 9e have been further evaluated for their effect on Topoisomerase I (TOPO I) and cancer cell cycle. It is concluded that the indolocarbazoles with alkyl piperazine or morpholine substituent groups instead of esters or glycosyl residues would have better activities against tumors.

Probing the efficiency of N-heterocyclic carbene promoted O- to C-carboxyl transfer of oxazolyl carbonates

(Chemical Equation Presented) Screening of a range of azolium salts, bases and solvents for reactivity indicates that triazolinylidenes, generated in situ with KHMDS in THF, promote the Steglich rearrangement of oxazolyl carbonates with high catalytic efficiency (typical reaction time 5 min at 1.5 mol % NHC). This protocol shows wide substrate applicability, even allowing the efficient generation of vicinal quaternary centers. An improved experimental procedure is also described that allows a simplified one-pot reaction protocol to be employed with similarly high catalytic efficiency.

Simple and effective preparation of amino sulfonylureas from amino acids: application to the synthesis of amino sulfonylurea-containing peptidomimetics

Several amino sulfonylureas have been synthesized, starting from amino acids. The synthetic procedure is simple affording high yields of products under mild conditions. Furthermore, it is shown that these compounds can be incorporated into a peptide sequence.