35541-11-8Relevant academic research and scientific papers
2,4,6-trisubstituted-1,3,5-s-triazine compound and preparation and application thereof
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Paragraph 0028; 0083, (2021/10/05)
The invention provides a 2,4,6-trisubstituted-1,3,5-s-triazine compound as well as preparation and application thereof, and biguanide or dimethyl biguanide hydrochloride is used as an initial raw material to react with a cyano compound under an alkaline condition to prepare the 2,4,6-trisubstituted-1,3,5-s-triazine compound. The invention provides a simple and convenient synthetic method of a 2,4,6-trisubstituted-1,3,5-s-triazine compound, and the compound provided by the invention can be applied to preparation of an anti-myelogenous leukemia medicine, namely an enasidenib medicine. Compared with the prior art, the method for preparing the enasidenib has the advantages that two-step reaction is reduced, the use of a halogenating reagent is avoided, and the method is a green and environment-friendly chemical process. The structural formula I is shown in the specification.
A New One-Pot Three-Component Synthesis of 4-Aryl-6-cycloamino-1,3,5-triazin-2-amines under Microwave Irradiation
Bin Shahari, Muhammad Syafiq,Junaid, Ahmad,Tiekink, Edward R. T.,Dolzhenko, Anton V.
, p. 2457 - 2468 (2021/03/18)
A new method for the fast synthesis of diverse 4-aryl-6-cycloamino-1,3,5-triazin-2-amines was developed. The synthesis is performed under microwave irradiation in a one-pot manner from cyanoguanidine, aromatic aldehydes, and cyclic amines. Their three-component reaction in the presence of hydrochloric acid produced dihydrotriazines, which were then converted (without isolation) into the targeted compounds via aromatic dehydrogenation in the presence of alkali. The reaction tolerated various aromatic aldehydes (including heterocyclic) and cyclic amines. Crystal structures of two representative 4-aryl-6-morpholino-1,3,5-triazin-2-amines were established by X-ray crystallography. The results of preliminary biological screening identified potent antileukemic activity for 6-[3,4-dihydroisoquinolin-2(1 H)-yl]-4-phenyl-1,3,5-triazin-2-amine.
Ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazines from alcohols and biguanides
Zeng, Ming,Wang, Tao,Cui, Dong-Mei,Zhang, Chen
supporting information, p. 8225 - 8228 (2016/10/11)
An efficient ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazines from alcohols and biguanides under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated benzyl alcohol containing functionalities s
2,4-diamine-1,3,5-triazine compound, preparation method and application thereof
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Paragraph 0030; 0031; 0032; 0033; 0034, (2016/12/07)
The invention provides a 2,4-diamine-1,3,5-triazine compound represented as the formula (III). A preparation method includes the following steps: adding compounds represented as the formulas (I) and (II), a metal copper catalyst, a ligand, an alkaline sub
NOVEL TRIAZINE COMPOUNDS
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Page/Page column 114, (2012/08/08)
The present invention relates to novel triazine compounds of formula (1), methods of their preparation, pharmaceutical compositions containing these compounds and the use of these compounds to treat proliferative disorders such as tumors and cancers and also other conditions and disorders related to or associated with dysregulation of PI3 Kinases, PI3 Kinase pathway, mTOR and/ or the mTOR pathway.
