3555-85-9

Basic information

• Product Name: 2 2' 4 4'-TETRAMETHOXYBENZOPHENONE 97
• Synonyms: 2 2' 4 4'-TETRAMETHOXYBENZOPHENONE 97
• CAS NO: 3555-85-9
• Molecular Formula: C₁₇H₁₈O₅
• Molecular Weight: 302.32182
• Mol File: 3555-85-9.mol

Chemical Properties

• Melting Point: 138-142 °C(lit.)
• Appearance: /
• CAS DataBase Reference: 2 2' 4 4'-TETRAMETHOXYBENZOPHENONE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 2 2' 4 4'-TETRAMETHOXYBENZOPHENONE 97(3555-85-9)
• EPA Substance Registry System: 2 2' 4 4'-TETRAMETHOXYBENZOPHENONE 97(3555-85-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 3555-85-9(Hazardous Substances Data)

Upstream product

• 131-55-5 2,2',4,4'-tetrahydroxybenzophenone 
• 60-29-7 diethyl ether 
• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 
• 591-51-5 phenyllithium 
• 79-37-8 oxalyl dichloride 
• 151-10-0 1,3-Dimethoxybenzene 
• 39828-35-8 2,4-dimethoxybenzoyl chloride 
• 7446-70-0 aluminium trichloride 
• 77-78-1 dimethyl sulfate 
• 64-17-5 ethanol 
• 131-54-4 bis(2-hydroxy-4-methoxyphenyl)-methanone 
• 135-77-3 1,2,4-trimethoxy-benzene 
• 78031-08-0 [(bromodifluoromethyl)sulfanyl]benzene 
• 108-98-5 thiophenol 

Downstream Products

• 4142-51-2 (2-hydroxy-4-methoxyphenyl) (2',4'-dimethoxyphenyl)methanone 
• 131-55-5 2,2',4,4'-tetrahydroxybenzophenone 
• 1416861-95-4 C₁₉H₂₄N₂O₄ 
• 116045-97-7 1,1-bis(2',4'-dimethoxyphenyl)ethylene 
• 86311-58-2 C₆H₃(OCH₃)2COC₆H₃(OCH₃)OBF₂ 
• 131-54-4 bis(2-hydroxy-4-methoxyphenyl)-methanone 

Relevant articles and documents

The compound of the chemical species generated

A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed.

Synthesis and anticancer potential of novel xanthone derivatives with 3,6-substituted chains

In an effort to develop new drug candidates with enhanced anticancer activity, our team synthesized and assessed the cytotoxicity of a series of novel xanthone derivatives with two longer 3,6-disubstituted amine carbonyl methoxy side chains on either benzene ring in selected human cancer cell lines. An MTT assay revealed that a set of compounds with lower IC50values than the positive control, 5-FU, exhibited greater anticancer effects. The most potent derivative (XD8) exhibited anticancer activity in MDA-MB-231, PC-3, A549, AsPC-1, and HCT116 cells lines with IC50values of 8.06, 6.18, 4.59, 4.76, and 6.09?μM, respectively. Cell cycle analysis and apoptosis activation suggested that the mechanism of action of these derivatives includes cell cycle regulation and apoptosis induction.

COMPOUNDERS FOR ENHANCING GENERATION OF CHEMICAL SPECIES

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Dicarbaporphyrinoid systems. Synthesis of oxo-adj-dibenziphlorins

A series of diformylbenzophenones were generated by sequentially reacting protected bromobenzaldehydes with n-butyllithium and ethyl N,N- dimethylcarbamate. The acetal protective groups were cleaved with refluxing formic acid. Vilsmeier-Haack formylation of 2,2′,4,4′- tetramethoxybenzophenone also afforded a related dialdehyde. MacDonald "2 + 2" condensation of three benzophenone dialdehydes with a dipyrrylmethane gave oxophlorin analogues constructed from two benzene and two pyrrole rings. The free base oxodibenziphlorins were rather unstable in solution, and in most cases these porphyrinoids were isolated as the corresponding trifluoroacetate salts. The spectroscopic properties of 6-oxo-adj-dibenziphlorins are consistent with a nonaromatic ring system. DFT calculations indicated that the macrocycles considerably diverge from planarity, particularly when methoxy substituents are present on the arene rings.

Friedel-crafts-type alkylation with bromodifluoro(phenylsulfanyl)methane through α-fluorocarbocations: Syntheses of thioesters, benzophenones and xanthones

Bromodifluoro(phenylsulfanyl)methane undergoes a Friedel-Crafts-type alkylation, through α-fluorocarbocations, with activated aromatic compounds yielding thioesters and/or benzophenones. The methodology has been applied to the synthesis of naturally occurring xanthone derivatives.

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The alkenyldiarylmethane (ADAM) HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are effective anti-HIV agents in cell culture. However, the potential clinical utility of the ADAMs is expected to be limited by the presence of methyl ester mo

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