35582-71-9

Upstream product

• 75327-41-2 2-[(3,4-Dimethoxy-phenyl)-(4-methoxy-phenyl)-methyl]-malonic acid 
• 94773-98-5 3-(3,4-Dimethoxy-phenyl)-3-(4-methoxy-phenyl)-propionic acid ethyl ester 
• 2033-89-8 3,4-dimethoxyphenol 
• 5854-22-8 dimethyl 2-(3,4-dimethoxybenzyl)malonate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 75327-40-1 2-[(3,4-Dimethoxy-phenyl)-(4-methoxy-phenyl)-methyl]-malonic acid dimethyl ester 
• 24393-56-4 ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate 

Downstream Products

• 94773-71-4 [2-(3,4-Dimethoxy-phenyl)-2-(4-methoxy-phenyl)-ethylcarbamoyloxy]-acetic acid ethyl ester 
• 122480-75-5 6,7-dimethoxy-4-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinol-1-one 
• 75327-45-6 N-methyl-3,4-dihydro-6,7-dimethoxy-4-(4-methoxyphenyl)-1-(2H)-isoquinolone 
• 75327-46-7 cherylline lactam 
• 75327-39-8 4-[2-Isocyanato-1-(4-methoxy-phenyl)-ethyl]-1,2-dimethoxy-benzene 
• 26996-80-5 4-(4-hydroxyphenyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 94773-76-9 (6R,10bS)-8,9-Dimethoxy-6-(4-methoxy-phenyl)-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one 

Relevant academic research and scientific papers

A Weinreb Amide Based Building Block for Convenient Access to β,β-Diarylacroleins: Synthesis of 3-Arylindanones

Towards the synthesis of symmetrical and unsymmetrical β,β-diarylacroleins for assembling diarylmethine fragments present in biologically important molecules, we have developed a new Weinreb amide (WA) based building block, derived from propiolic acid. The WA functionality present in this compound allowed the sequential addition of various arylmagnesium bromide reagents in a controlled manner. The developed methodology for the access to β,β-diarylacroleins has been utilised for the synthesis of biologically important 3-arylindanone molecules. Synthesis of both symmetrical and unsymmetrical β,β-diarylacrolein and diarylmethine fragments, have been achieved via easily accessible and hitherto unknown Weinreb Amide (WA) based building block 11. The WA functionality allowed the sequential addition of nucleophiles such as arylmagnesium bromide in a controlled manner, which has enabled the synthesis of an important 3-arylindanone molecule.

Synthesis of Amaryllidaceae Alkaloids, (+/-)-Cherylline and (+/-)-Latifine

Synthesis of the alkaloids, (+/-)-cherylline (1) and (+/-)-latifine (2), was accomplished by application of an isocyanate cyclization reaction according to Tsuda's two step procedure for constructing 1,2,3,4-tetrahydroisoquinol-1-one and a regioselective

A STEREOSELECTIVE SYNTHESIS OF 5-ARYL- AND 6-ARYLOXAZOLOISOQUINOLINES

Reduction of N-(α,β-diaryl)ethyl and N-(β,β-diaryl)ethyl ethoxycarbonylmethyl carbamates, obtained from the corresponding 2,3-diaryl- and 3,3-diarylpropionic acids, with diisobutylaluminum hydride, followed by cyclization with formic acid at room temperature gave the corresponding 5-aryl and 6-aryl-oxazoloisoquinolines, respectively, with high stereoselectivity.

NEW SYNTHESIS OF ISOQUINOLINE ALKALOIDS, THALIFOLINE, CORYPALLINE, AND CHERYLLINE

Isoquinoline alkaloids, thalifoline, corypalline, and cherylline, were synthesised by application of the cyclisation reaction of β-phenyl-ethyl isocyanate to N-methylisoquinoline lactam with Magic Methyl and the regioselective cleavage reaction of aromatic methoxyl groups with methionine and methanesulphanic acid.