35666-79-6

Upstream product

• 123-75-1 pyrrolidine 
• 151-50-8 potassium cyanide 
• 67-64-1 acetone 
• 7677-24-9 trimethylsilyl cyanide 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 

Downstream Products

• 896119-95-2 (+/-)-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]amine 
• 97061-77-3 C₁₄H₂₀N₂ 

Relevant academic research and scientific papers

Heterogeneously catalysed Strecker-type reactions using supported Co(ii) catalysts: Microwave vs. conventional heating

A range of α-aminonitriles could be efficiently prepared from various aldehydes/ketones and primary or secondary amines using a highly active and stable Co(ii) complex supported on different mesoporous supports at both room temperature and low temperature microwave irradiation under solventless conditions. Catalysts were also highly reusable under the investigated reaction conditions and could be reused at least 10 times without loss of catalytic activity. The Royal Society of Chemistry.

Efficient Co(ii) heterogeneously catalysed synthesis of α-aminonitriles at room temperature via Strecker-type reactions

An environmentally friendly and highly active mesoporous Co(ii) complex on mesoporous SBA-15 material could be used as an easily recoverable catalyst for the synthesis of α-aminonitriles from a wide range of aldehydes/ketones and primary or secondary amines with good to excellent conversions yields at room temperature under solventless conditions. The catalyst can be recovered by simple filtration and could be reused at least 10 times without loss of catalytic activity.

PYRROLIDINE DERIVATIVES HAVING ACTIVITY AT THE GLYT1 TRANSPORTER

The succinate and napadisylate salts and solvates of 2-(Methyloxy)-/V-[2-methyl-1-phenyl-2- (1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide,6-bis(trifluoromethyl)benzamide napadisylate, and uses thereof in the treatment of disorders relating to

GLYCINE TRANSPORTER INHIBITING COMPOUNDS AND USES IN MEDICINE

Compounds of formula (I) and salts and solvates thereof are provided: wherein R1 and R2 are both methyl, or R1 and R2 form a pyrrolidinyl group. Uses in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, such as psych

GLYCINE TRANSPORTER INHIBITING COMPOUNDS AND USES IN MEDICINE

Compounds of formula (I) and salts and solvates thereof are provided: wherein either 1 ) R1, R2, R3 and R4 and all methyl, or 2) R1 and R2 form a pyrrolidinyl group and R3 and R4 are both methyl, or 3) R1 and R2 are both methyl and R3 and R4 together form

2-AMINO-1-PHENYLETHYLCARBOXAMIDE DERIVATIVES

The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. Formula (I) wherein R1 is a group selected from: Formulas (A), (B), (C)

Nickel catalysed coupling of allylamines and boronic acid

Allylamines function as substrates for cross-coupling with boronic acids in the presence of nickel(0) catalysts rather than palladium(0) catalysts.Aryl-, vinyl- and methyl-boronic acids function well.With vinyl derivatives, E-isomers couple more efficiently than Z-isomer and both fully retain the geometrical integrity.Methylations preferably employ the boronic esters like 2-methyl-1,3,2-benzodioxaborole or 2-methyl-1,3,2-dioxaborolane rather than methylboronic acid.The stereochemistry of the reaction involves a net inversion with respect to the allylamine.The regioselectivity is a function of ligand.Generally, sterically bulky donor phosphines promote new C-C bond formation at the less substituted position.Bidentate ligands, notably 1,1'-binaphthyl-2,2'-ylbis(diphenylphosphinite) (BINAPO), promote new C-C bond formation at the more substituted allyl terminus.The amines appear to be the preferred partner compared to allyl alcohols and esters with the boronic acids and give higher stereospecificity.

A FAST N-SUBSTITUTED α-AMINONITRILE SYNTHESIS

A series of α-aminonitriles bearing various functionalities was prepared by reacting a neat mixture of an aldehyde or ketone, an amine and trimethylsilyl cyanide.The reaction was essentially complete in 5 minutes.