35697-10-0

Basic information

• Product Name: 5-Hydroxy-2-tetralone
• Synonyms: 5-HYDROXY-2-TETRALONE;5-Hydroxy-3,4-dihydronaphthalen-2(1H)-one;5-hydroxyl-2-tetralone;3,4-Dihydro-5-hydroxynaphthalen-2(1H)-one;4-dihydro-5-hydroxy-;5-hydroxy-1,2,3,4-tetrahydronaphthalen-2-one
• CAS NO: 35697-10-0
• Molecular Formula: C10H10O2
• Molecular Weight: 162.19
• Mol File: 35697-10-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 333.63 °C at 760 mmHg
• Flash Point: 141.842 °C
• Appearance: /
• Density: 1.236 g/cm³
• Vapor Pressure: 6.96E-05mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: 5-Hydroxy-2-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Hydroxy-2-tetralone(35697-10-0)
• EPA Substance Registry System: 5-Hydroxy-2-tetralone(35697-10-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 35697-10-0(Hazardous Substances Data)

Usage

General Description

5-Hydroxy-2-tetralone is a chemical compound with the molecular formula C10H10O2. It is a member of the tetralone family and contains a hydroxy group at the 5-position of the molecule. 5-Hydroxy-2-tetralone is an important intermediate in the synthesis of various pharmaceuticals and organic compounds. It is used as a building block in the synthesis of natural products and biologically active molecules. 5-Hydroxy-2-tetralone has been studied for its potential anti-inflammatory and antioxidant properties, and its unique structure makes it a valuable target for chemical synthesis and drug development. Overall, 5-Hydroxy-2-tetralone is a versatile and important chemical compound with potential applications in various fields, including medicine and materials science.

InChI:InChI=1/C10H10O2/c11-8-4-5-9-7(6-8)2-1-3-10(9)12/h1-3,12H,4-6H2

Upstream product

• 74-85-1 ethene 
• 32940-15-1 5-methoxy-2-tetralone 
• 22604-07-5 6-methoxy-1-naphthol 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 100884-30-8 1,6-bis-methoxymethoxy-naphthalene 
• 575-44-0 1,6-dihydroxynaphthalene 

Downstream Products

• 143325-87-5 2,5-dihydroxy-1,2,3,4-tetrahydronaphthalene 

Relevant articles and documents

Synthesis method of 5-hydroxy-2-tetralone

The invention discloses a synthesis method of 5-hydroxy-2-tetralone. The method comprises the following steps: reacting 3-hydroxyphenylacetic acid with thionyl chloride in the presence of a catalyst solvent to obtain a reaction product containing 3-hydroxyphenylacetyl chloride; recrystallizing the obtained product in normal hexane to obtain purified 3-hydroxyphenylacetyl chloride; reacting 3-hydroxyphenylacetyl chloride with ethylene in the presence of a catalyst solvent to obtain a reaction product containing 5-hydroxy-2-tetralone; and adding hydrochloric acid to adjust the pH value of the product to 3, extracting and separating liquid in an acidic atmosphere, and carrying out column chromatography to obtain purified 5-hydroxy-2-tetralone. According to the invention, the conditions of the reaction steps are mild, the operation is simple and convenient, the initial raw materials are cheap and easy to obtain, the reaction steps are short, the generated three-waste pollutants are less, the yield is high, the method is suitable for industrial large-scale production, the reaction steps are simplified to a certain extent, and the subsequent reaction is facilitated.

Enzymatic resolution of 5-hydroxy- and 8-hydroxy-2-tetralols using immobilized lipases

(R)-2-Tetralol (R)-2a, (R)-5-hydroxy-2-tetralol (R)-2b and (R)-8-hydroxy-2-tetralol (R)-2c, which are key intermediates in the synthesis of pharmacologically active 2-aminotetralins 3, were prepared in moderate to very high enantiomeric excess (up to 99% ee) by enzymatic resolution of the corresponding racemic butyrates rac-1a, rac-1b and rac-1c, respectively, using lipases immobilized on octyl agarose. This methodology is an alternative to the microbial reduction of 2-tetralones.

HYDROXYLATION DU BENZALDEHYDE ET DE CETONES AROMATIQUES PAR LE PEROXYDE D'HYDROGENE EN MILIEU SUPERACIDE

Benzaldehyde and aromatic ketones are hydroxylated by hydrogen peroxide in SbF5-HF without formation of products arising from Baeyer-Villiger oxidation.