357933-30-3

Basic information

• Product Name: (4R,5S)-4-methyl-5-phenyldihydrofuran-2(3H)-one
• Synonyms: (4R,5S)-4-methyl-5-phenyldihydrofuran-2(3H)-one
• CAS NO: 357933-30-3
• Molecular Weight: 176.215
• Mol File: 357933-30-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4R,5S)-4-methyl-5-phenyldihydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-4-methyl-5-phenyldihydrofuran-2(3H)-one(357933-30-3)
• EPA Substance Registry System: (4R,5S)-4-methyl-5-phenyldihydrofuran-2(3H)-one(357933-30-3)

Safety Data

• Hazardous Substances Data: 357933-30-3(Hazardous Substances Data)

Upstream product

• 21053-63-4 methyl-3 phenyl-4 Δ²⁽³⁾-butyrolactone 
• 67-56-1 methanol 
• 74-95-3 1,1-dibromomethane 
• 76549-03-6 methyl (2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoate 
• 100-52-7 benzaldehyde 
• 77877-25-9 (4S)-3-((2S,3S)-3-hydroxy-2-methyl-1-oxo-3-phenylpropyl)-4-(1-methylethyl)-2-oxazolidinone 

Relevant articles and documents

Kinetic Resolution and Dynamic Kinetic Resolution of γ-Aryl-Substituted Butenolides via Copper-Catalyzed 1,4-Hydroboration

Kinetic resolution (KR) and dynamic kinetic resolution (DKR) of γ-aryl and heteroaryl-substituted butenolides via CuH-catalyzed 1,4-hydroboration using pinacolborane is reported. With a copper-Ph-BPE catalyst, selectivity factors were extremely high (s=>400) with regard to the kinetic resolution of β-methyl-γ-phenyl butenolide; DKR was possible in the presence of an amine base (DBU), which facilitated racemization of the starting unsaturated lactones. The reaction provided easy access to highly enantioenriched γ-butyrolactones (>99% ee) containing β,γ-substituents. (Figure presented.).