97531-43-6

Upstream product

• 111221-89-7 Toluene-4-sulfonic acid 2-cyclohexyl-2-hydroxy-ethyl ester 
• 27126-76-7 [hydroxy(tosyloxy)iodo]benzene 
• 823-76-7 Cyclohexyl methyl ketone 
• 104-15-4 toluene-4-sulfonic acid 
• 3483-39-4 Cyclohexyloxirane 

Downstream Products

• 97531-41-4 2-Cyclohexyl-2-(diphenyl-phosphinoyl)-oxirane 
• 97531-38-9 (1-cyclohexylethenyl)diphenylphosphine oxide 
• 70059-10-8 dimethyl 1-cyclohexylvinylphosphonate 
• 3483-39-4 (S)-2-cyclohexyloxirane 
• 357952-91-1 (S)-(+)-1-Cyclohexyl-2-(p-tolylsulfonyloxy)ethanol 

Relevant academic research and scientific papers

General Method for the Preparation of Electron-Deficient Imidazo[1,2-a]pyridines and Related Heterocycles

A new annulation method for the preparation of the imidazo[1,2-a]pyridine ring system under mild conditions is presented. Treatment of a 2-aminopyridine with a dimethylketal tosylate in acetonitrile at elevated temperature (80-140°C) in the presence of catalytic Sc(OTf)3 provides the imidazo[1,2-a]pyridine product in good yield. The annulation method is broadly applicable to electron-poor 2-aminopyridines and displays a complementary profile to the classic preparation of the imidazo[1,2-a]pyridine ring system by reaction of a bromoketone with electron-rich and -neutral substrates. The scope of the process and mechanistic considerations are discussed.

Reaction of Terminal Oxiranes With Arenesulfonic Acid

The reaction of oxiranes 1 with arenesulfonic acids under phase transfer catalyst system (water/dichloromethane) or without catalyst (dry dichloromethane) affords regioisomeric arylsulfonyloxy primary and secondary alcohols.The latter is oxidized to 1-arylsulfonyloxy-2-alkanones 5 in good yield.