3583-85-5

Upstream product

• 69381-90-4 (1-phenylethane-1,2-diyl)bis(diphenylphosphine) 
• 536-74-3 phenylacetylene 
• 4559-70-0 Diphenylphosphine oxide 
• 618-34-8 1-chlorostyrene 
• 622-25-3 1-(2-chlorovinyl)benzene 
• 20780-53-4 (R)-Styrene oxide 
• 829-85-6 diphenylphosphane 
• 795-47-1 β-Diphenylphosphinylstyrol 
• 1079-66-9 chloro-diphenylphosphine 
• 795-47-1 (E)-diphenyl(styryl)phosphine oxide 
• 69381-91-5 (-)-(R)-1,2-bis(diphenylphosphino)-1-phenylethane 
• 74497-20-4 (+)-(S)-1-phenylethane-1,2-diol dimethanesulphonate 
• 25779-13-9 (S)-1-phenyl-1,2-ethanediol 
• 17199-29-0 (S)-Mandelic acid 

Downstream Products

• 69381-90-4 (1-phenylethane-1,2-diyl)bis(diphenylphosphine) 
• 795-47-1 (E)-diphenyl(styryl)phosphine oxide 
• 3582-84-1 (2-phenylethyl)diphenylphosphine oxide 

Relevant academic research and scientific papers

An efficient base-catalyzed double addition of H-phosphine oxides to alkynes

An efficient base-catalyzed double addition of H-phosphine oxides to alkynes is developed. In the presence of a catalytic amount of a base, the addition of various H-phosphine oxides to both aromatic and aliphatic alkynes took place efficiently to produce the corresponding bisphosphoryl compounds in excellent yields. This method provides an easy direct way to prepare bisphosphine oxides that are of high importance in organic synthesis.

Alkali Metal Catalysed Double Hydrophosphorylation of Nitriles and Alkynes

Catalytic C–P and N–P bond formation via double hydrophosphorylation of nitriles with diphenylphosphane oxide using alkali metal precatalyst [MN(SiMe3)2] (M = Li, Na, K) is reported. The potassium congener was observed to be the most

Regioselective Single and Double Hydrophosphination and Hydrophosphinylation of Unactivated Alkynes

A lanthanum-based N,N-dimethylbenzylamine complex was used as a precatalyst for both hydrophosphination and hydrophosphinylation of alkynes under mild conditions. In the case of hydrophosphination, the catalyst induced monoaddition with high regiospecific

BISPHOSPHINE OXIDE COMPOUND, BIS-THIO-PHOSPHINE COMPOUND, OR METHOD FOR PRODUCING BISPHOSPHINE COMPOUND

PROBLEM TO BE SOLVED: To provide a general synthesis method of various bisphosphine compounds and derivatives thereof by using raw materials that are easily available and easy to handle. SOLUTION: A bisphosphine oxide compound, a bis-thio-phosphine compou

T-BuOK-mediated reductive addition of P(O)-H compounds to terminal alkynes forming β-arylphosphine oxides

A novel and efficient t-BuOK-mediated reductive addition of P(O)-H compounds to terminal alkynes was developed. A variety of β-arylphosphine oxides including the valuable β-heteroarylphosphine oxides were produced in moderate to high yields under mild reaction conditions. This reaction may proceed via a tandem process involving regio-selective double addition and subsequent transfer hydrogenation.

DOUBLE ADDITION OF PHOSPHINE OXIDE TO ALKYNE WITH BASE CATALYST

PROBLEM TO BE SOLVED: To provide a method of synthesizing a phosphorus compound by double addition of phosphine oxide to alkyne with a base catalyst. SOLUTION: The present invention provides a method comprising the step of reacting alkyne and a phosphorus compound in an ether solvent in the presence of a catalytic amount of a base. The method of production according to the present invention (1) allows a reduction in remaining metal components in the product and (2) a reduction in production cost and (3) has an expanded scope of substrates in comparison with the conventional methods of production. Moreover, the obtained compounds may be used in flame retardants, lubricant additives, pharmaceutical intermediates, and catalyst raw materials. Furthermore, phosphine compounds that are obtained by reducing the compounds obtained by this reaction are compounds useful as ligands. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

Air-induced double addition of P(O)-H bonds to alkynes: A clean and practical method for the preparation of 1,2-bisphosphorylethanes

An air-induced double addition of diphenyl phosphine oxide to various alkynes is reported. This reaction can proceed efficiently under metal- and solvent-free conditions, and is a clean and practically useful method for the preparation of the valuable 1,2

Br?nsted Base Mediated Stereoselective Diphosphination of Terminal Alkynes with Diphosphanes

A Br?nsted base mediated stereoselective diphosphination of terminal alkynes with diphosphanes proceeds to deliver the corresponding (E)-1,2-diphosphinoethenes in good yields. The reaction of aromatic alkynes occurs efficiently in the presence of a catalytic amount of LiO-t-Bu while MN(TMS)2 (M = Li or Na) gave better results in the case of aliphatic substrates. The Br?nsted base mediated protocol can offer a good alternative to precedented transition-metal-catalyzed or radical-promoted approaches to the 1,2-diphosphinoethene framework of potent interest in catalysis and coordination chemistry.

Reactions of Manganese and Rhenium Vinylidene Complexes with Hydrophosphoryl Compounds

We studied the reactions of manganese and rhenium phenylvinylidenes Cp(CO)2MCC(H)Ph (Mn1 M = Mn; Re1 M = Re) with HP(O)R2 (R = C6F5, Ph, and OEt) and HP(S)Ph2, which resulted in the selective formation of η2-E-phosphorylalkene complexes Cp(CO)2M{η2-E-H[R2(O)P]CC(H)Ph} (Mn2, Re2 R = C6F5; Mn3, Re3 R = Ph; and Mn6, Re6 R = OEt) and Cp(CO)2M{η2-E-H[Ph2(S)P]CC(H)Ph} (Mn5, Re5). The DFT/B3LYP(6-31G*) analysis showed the model reactions of Mn1 with HP(O)Me2 and HP(O) (OMe)2 to proceed via the initial transition state Cp(CO)2{Ph(H)CC}Mn···HO-PR2 (TS1) where the minor PA form HO-PR2 is hydrogen-bonded to the metal, followed by stereoselective (trans- to the phenyl group) addition of the PA phosphorus atom to the Cα-vinylidene atom, which defines both the rate of the process and the anti-Markovnikov structure of the reaction product. The reactions can proceed at a relatively low content of the reactive PA form.

Nickel(II)-magnesium-catalyzed cross-coupling of 1,1-dibromo-1-alkenes with diphenylphosphine oxide: One-pot synthesis of (E)-1-alkenylphosphine oxides or bisphosphine oxides

A novel nickel(II)-magnesium-mediated cross-coupling of diphenylphosphine oxide with a variety of 1,1-dibromo-1-alkenes has been developed, which provides a powerful and general methodology for the stereoselective synthesis of various (E)-1-alkenylphosphine oxides or bisphosphine oxides, with operational simplicity of the procedure, good to high yields and broad substrate applicability. Mechanistic studies reveal that the reaction might involve a Hirao reduction, cross-coupling and Michael addition. Copyright