358638-36-5Relevant academic research and scientific papers
Preparation method of ranitidine hydrochloride with low NDMA content
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Paragraph 0016-0019, (2020/12/15)
The invention relates to the technical field of ranitidine hydrochloride preparation, in particular to a preparation method of ranitidine hydrochloride with low NDMA content, which comprises the following steps: adding a ranitidine base into ethanol, and stirring until complete dissloving is achieved; cooling the solution to -5 to 5 DEG C; controlling the temperature, adding a hydrochloric acid aqueous solution, adjusting the pH value to 4.5-6.5, and uniformly stirring; adding a seed crystal, preserving heat, stirring and crystallizing for 3-5 hours; and filtering a crystal, washing, drainingand drying to obtain the off-white crystal solid ranitidine hydrochloride. The salifying method disclosed by the invention has the advantages that the steps are simple, the raw material hydrochloric acid aqueous solution is easy to obtain, the product character is good, and the impurity content of the final product NDMA (N-Nitrosodimethylamine) is low.
Preparation method of high-transmittance ranitidine hydrochloride
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Paragraph 0014; 0015, (2017/12/27)
The invention discloses a preparation method of high-transmittance ranitidine hydrochloride. The preparation method comprises the following steps: (1) preparing a raw material solution; (2) preparing ranitidine by virtue of reaction; (3) purifying the ranitidine; (4) preparing ranitidine hydrochloride; (5) purifying the ranitidine hydrochloride. According to the preparation method of the high-transmittance ranitidine hydrochloride, by reasonably improving the process, controlling the temperature, controlling the stirring rate and controlling a dropwise adding rate of crystal solvent absolute ethyl alcohol as well as controlling the vacuum reaction conditions, the yield and purity of the ranitidine hydrochloride are effectively increased, the implementation feasibility of the production process is high, the industrialized mass production is facilitated, the obtained product is high in transmittance and transmission stability, good in crystal form, good in mobility, excellent in comprehensive performance, and high in practical application and market development value.
Preparation of acid addition salts of amine bases by solid phase-gas phase reactions
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Page/Page column 3, (2008/06/13)
A process for the preparation of an acid addition salt of an organic base comprising exposing the organic base in solid form to a gaseous acid, with the proviso that ziprasidone, its acid addition salts and intermediates thereof are excluded.
ANHYDROUS TABLET OF RANITIDINE HYDROCHLORIDE WITH DOUBLE-LAYER COATING AND ITS COMPOSITION
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Page/Page column 7, (2008/06/13)
The invention concerns an anhydrous tablet containing anhydrous ranitidine hydrochloride, coated by a double-layer coating, its composition and the relevant process of preparation. The anhydrous tablet of the invention is characterized by the direct dry tabletting, without using water, of a mixture consisting of the active ingredient anhydrous ranitidine hydrochloride, in the crystalline form "allomorphous Form 1" having a particular purity and stability, and by a global amount of other excipients and adjuvant substances or inert vehicles less than the weight of the active ingredient. Moreover, the anhydrous tablet of the invention is characterized by a high percentage of disintegrating substance in the tabletting mixture and by a special two-layer coating.
Allomorph of isomer Z hydrochloride of alkylaminofurane derivative
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Page/Page column 6, (2008/06/13)
Allomorph of Z isomer of N-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]-N′-methyl-2-nitro-1,1-ethenediamine hydrochloride, with two carbon atoms linked by a rigid ethylenic bond, marked by an asterisk (*), characterized by the following structural formula: wherein -Fur- represents a furane ring.
Novel process for the preparation of form 1 ranitidine hydrochloride
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, (2008/06/13)
The present invention provides a novel process for preparing Form 1 ranitidine hydrochloride by crystallization from at least one C1-C6 alkanol.
Process for the manufacture of form 1 ranitidine hydrochloride
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, (2008/06/13)
A process for the manufacture of Form 1 ranitidine hydrochloride (N-[2-[[[5-(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl-N'-methyl-2-nitro-1,1-ethenediamine) hydrochloride, is described. A process to convert ranitidine hydrochloride Form 2 to Form 1 is also described.
Amine acid salt compounds and process for the production thereof
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, (2008/06/13)
A stoichiometric acid moiety transfer reaction for the preparation of an acid salt of an amine compound is disclosed. The acid moiety transfer reaction provides amine acid salts of high purity and having crystalline structure of uniform size and shape.
Process for preparing form 1 ranitidine hydrochloride
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, (2008/06/13)
A process for preparing pure N-[2-[[[5-[dimethylamino)-methyl-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethyldiamine hydrochloride, designated Form 1 ranitidine hydrochloride, from ranitidine in methylene chloride with the addition of hydrochloric acid. The Form 1 ranitidine hydrochloride thus obtained is stable and therefore useful for producing commercial-scale quantities of Form 1 ranitidine hydrochloride.
Form of form 1 Ranitidine
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, (2008/06/13)
Process for the production of an improved form of Form 1 Ranitidine Hydrochloride having improved filtration and drying characteristics, said process comprising in a substantially anhydrous hydroxylic solvent, comprising at least one alkanol solvent having 3-4 carbon atoms, adding anhydrous hydrogen chloride gas to Ranitidine free base wherein said substantially anhydrous hydroxylic solvent has the characteristics that it solubilizes the Ranitidine free base and hydrogen chloride gas, and subsequently recovering the improved form of Form 1 Ranitidine Hydrochloride.
