168127-08-0

Basic information

• Product Name: N-METHYL-1-(METHYLTHIO)-2-NITROETHYLEN-1-AMINE
• Synonyms: N-METHYL-1-(METHYLSULFANYL)-2-NITRO-1-ETHYLENAMINE;N-METHYL-N-[1-(METHYLSULFANYL)-2-NITROVINYL]AMINE
• CAS NO: 168127-08-0
• Molecular Formula: C₄H₈N₂O₂S
• Molecular Weight: 148.18
• EINECS: 263-266-9
• Mol File: 168127-08-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-METHYL-1-(METHYLTHIO)-2-NITROETHYLEN-1-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYL-1-(METHYLTHIO)-2-NITROETHYLEN-1-AMINE(168127-08-0)
• EPA Substance Registry System: N-METHYL-1-(METHYLTHIO)-2-NITROETHYLEN-1-AMINE(168127-08-0)

Safety Data

• Hazardous Substances Data: 168127-08-0(Hazardous Substances Data)

Usage

Uses

N-Methyl-1-(methylsulfanyl)-2-nitro-1-ethylenamine is used in preparation of Allomorphs of (Z)-Ranitidine Hydrochloride.

Upstream product

• 18805-25-9 methyl carbonimidodithioic acid dimethyl ester 
• 74-89-5 methylamine 
• 13623-94-4 1,1-di(methylsulfanyl)-2-nitroethylene 

Downstream Products

• 667463-27-6 (Z)-N-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine 
• 358638-36-5 ranitidine hydrochloride 
• 878905-29-4 C₁₂H₁₁Cl₂N₃O₃S 

Relevant articles and documents

Catalyst-free synthesis of thiazolidines: Via sequential hydrolysis/rearrangement reactions of 5-arylidenethiazolidin-4-ones at room temperature

A catalyst-free sequential reaction involving hydrolysis and intramolecular aza-Michael addition was developed for synthesizing functionalized thiazolidines from 5-arylidenethiazolidin-4-ones at room temperature. A series of thiazolidine-5-carboxylic acids were prepared in good to excellent yields (up to 97% yield) and excellent diastereoselectivities (up to >20:1 dr). This methodology was applicable to the construction of derivatives of thiacloprid and flutianil with good yields.

Improved process for the preparation of 1-substituted amino-1-substituted thio-2-nitro alkenes

A process is disclosed for the manufacture of 1-substituted amino-1-substituted thio-2 nitro alkenes of the general formula: (R1NH) (R2S) C=CR3 (NO2) wherein R1, R2, R3, may be same or different and may consist of hydrogen, alkyl, aryl or arylalkyl groups