667463-27-6

Upstream product

• 66356-53-4 5-{[(2-aminoethyl)thio]methyl}-N,N-dimethyl-2-furfurylamine 
• 168127-08-0 (Z)-N-methyl-1-methylthio-2-nitroethenamine 
• 143-07-7 lauric acid 
• 50-81-7 ascorbic acid 
• 57-10-3 1-hexadecylcarboxylic acid 

Downstream Products

• 358638-36-5 ranitidine hydrochloride 

Relevant academic research and scientific papers

Process for the manufacture of pharmaceutical grade ranitidine base

A process for the manufacture of pharmaceutical grade ranitidine base(N-?2-???5-(Dimethylamino)methyl!-2-furanyl!methyl!thio!ethyl-N'-methyl-2-nitro-1, 1-ethenediamine), is described. In-vitro and in-vivo pharmacological studies and acute toxicity studies indicate that it is as active and as safe as Form 2 ranitidine hydrochloride.

Process for preparing H2 receptor antagonist ascorbate compounds

H2 -receptor antagonist ascorbate compounds, derived from the lactone form of 3-ketohexuronic acid of Formula STR1 where (X) may be 1, 2 or 3 and (Y) may be 1 or 2, R1 and R2 are both hydrogen or R1 may be hydroxyl, R2 hydrogen or the O-alkylidene, 5,6-diacyl, 6-acyl derivatives thereof having two to sixteen carbon atoms, or a 6-phosphate, R3 being an organic base or a salt thereof having one or more basic functional groups, having H2 -receptor antagonist properties and capable of reacting with nitrous acid, and a process for the preparation of said compounds.