765943-20-2Relevant academic research and scientific papers
A new approach to the synthesis of N,N-dialkyladenine derivatives
Alves, M. Jose,Carvalho, M. Alice,Carvalho, Silvia,Dias, Alice M.,Fernandes, Francisco H.,Proenca, M. Fernanda
, p. 4881 - 4887 (2007)
N,N-Dialkyladenine derivatives were prepared by two different reaction sequences starting from 5-amino-4-cyanoformimidoylimidazoles. When these imidazoles were treated with dimethylformamide diethyl acetal, a 5-aminomethyleneamino-4-cyanoformimidoylimidazole was isolated and evolved to the N,N-dialkyladenine in the presence of a secondary alkylamine. The same purine structure was isolated when the 5-amino-4-cyanoformimidoylimidazole was first treated with a secondary amine to give a stable 4-amidino-5- aminoimidazole. The desired product was generated when the 4-amidino-5- aminoimidazole was combined with dimethylformamide diethyl acetal, at room temperature. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
