35893-90-4

Upstream product

• 2142-69-0 2-bromophenyl methyl ketone 
• 69922-38-9 Methyl 3,4-dimethoxyphenyldithiocarboxylate 
• 147-93-3 Thiosalicylic acid 
• 26824-02-2 1-(2-mercaptophenyl)ethan-1-one 
• 1198288-53-7 C₁₇H₁₆O₄S 
• 1314533-40-8 C₁₇H₁₆O₄S 
• 117968-39-5 1-[2-(4-methoxybenzylthio)phenyl]-2-(methylsulfinyl)ethanone 
• 117968-38-4 methyl 2-(4-methoxybenzylthio)benzoate 
• 4892-02-8 Methyl thiosalicylate 
• 117968-42-0 2-(3,4-Dimethoxy-phenyl)-3-methanesulfinyl-thiochroman-4-one 
• 4687-37-0 ethyl 3,4-dimethoxybenzoylacetate 
• 108-98-5 thiophenol 

Relevant academic research and scientific papers

Copper-Catalyzed One-Pot Synthesis of 2-Arylthiochromenones: An in Situ Recycle of Waste Byproduct as Useful Reagent

Copper-catalyzed one-pot synthesis of various 2-arylthiochromenones is developed using xanthate as an odorless sulfur source from easily acquirable 2′-halochalcones. This methodology demonstrates that the cross-coupled product thiochromanone synthesized from 2′-halochalcones (upstream reaction) is oxidized to thiochromenone (downstream reaction) in the same pot using waste byproduct (KI) of the first step as powerful oxidant molecular iodine (I2). This one-pot synthesis has been further extended for the synthesis of 3,3′-methylenebisthioflavone using dimethyl sulfoxide (DMSO) as solvent and methylene source.

Transition metal free intramolecular S-arylation: One-pot synthesis of thiochromen-4-ones

A convenient one-pot method for the synthesis of thiochromen-4-ones by the condensation of 2′-haloacetophenone and dithioesters at room temperature in the presence of NaH in DMF in moderate to good yields has been developed. The method involves unusual intramolecular S-arylation. The reaction is operationally facile, readily scalable and offers rapid entry into substituted chromene-4-ones.

Microwave-assisted three-component coupling-addition-SNAr (CASNAR) sequences to annelated 4H-thiopyran-4-ones

A whole family of annelated 4H-thiopyran-4-ones as the core structural unit was readily synthesized in good yields by a microwave-assisted coupling-addition-SNAr (CASNAR) sequence starting from readily available (het)aroyl chlorides, alkynes and sodium sulfide nonahydrate in a consecutive one-pot three-component reaction. All representatives display a pronounced halochromicity of the absorption bands upon protonation. According to DFT calculations, the electronic ground state of the annelated 4H-thiopyran-4-ones possess a considerable zwitterionic character. The Royal Society of Chemistry 2010.

A novel consecutive three-component coupling-addition-SNAr (CASNAR) synthesis of 4H-thiochromen-4-ones

4H-Thiochromen-4-ones and 4H-thiopyrano[2,3-b]pyridin-4-ones are readily synthesized in good yields by a consecutive one-pot, three-component coupling-addition-SNAr (CASNAR) sequence starting from aroyl chlorides, alkynes, and sodium sulfide no

A New Preparation of Substituted 4H-1-Benzothiopyran-4-ones from C(α),N-Benzoylhydrazones or C(α),N-Carboalkoxyhydrazones and Methyl Thiosalicylate

C(α),N-Benzoylhydrazones or C(α),N-carboalkoxyhydrazones were dilithiated with excess lithium diisopropylamide, and the dianion-type intermediates were condensed with lithiated methyl thiosalicylate, followed by cyclization/hydrolysis to substituted 4H-1-benzothiopyran-4-ones (thioflavones/thiochromones).

A NEW SYNTHESIS OF THIOFLAVONES

A new synthesis of thioflavones from β-keto sulphoxide (12) is described.