26824-02-2

Basic information

• Product Name: 2-mercaptoacetophenone
• Synonyms: 2-mercaptoacetophenone;1-(2-Mercaptophenyl)ethanone;o-Mercaptoacetophenone;Ethanone, 1-(2-Mercaptophenyl)-;1-(2-MERCAPTOPHENYL)ETHAN-1-ONE
• CAS NO: 26824-02-2
• Molecular Formula: C₈H₈OS
• Molecular Weight: 152.21352
• Mol File: 26824-02-2.mol

Chemical Properties

• Boiling Point: 250℃
• Flash Point: 105℃
• Appearance: /
• Density: 1.139
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.568
• PKA: 5.78±0.43(Predicted)
• CAS DataBase Reference: 2-mercaptoacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-mercaptoacetophenone(26824-02-2)
• EPA Substance Registry System: 2-mercaptoacetophenone(26824-02-2)

Safety Data

• Hazardous Substances Data: 26824-02-2(Hazardous Substances Data)

Usage

Uses

Used in Food and Cosmetic Industry:
2-Mercaptoacetophenone is used as a fragrance and flavoring agent for its distinct aroma, enhancing the sensory experience of various products in these industries.
Used in Organic Synthesis:
As a reagent, 2-mercaptoacetophenone is utilized in organic synthesis, contributing to the creation of a wide array of chemical compounds for different applications.
Used in Pharmaceutical Industry:
2-Mercaptoacetophenone is used as a chelating agent in pharmaceuticals, playing a crucial role in the development of drugs that require metal ion binding properties.
Used in Agrochemicals:
In the agrochemical sector, 2-mercaptoacetophenone is employed for its potential applications in the development of pesticides and other agricultural chemicals, where its chelating properties can be advantageous.
These applications highlight the diverse utility of 2-mercaptoacetophenone across different industries, underscoring its importance as a chemical intermediate and active ingredient.

InChI:InChI=1/C8H8OS/c9-8(6-10)7-4-2-1-3-5-7/h1-5,10H,6H2

Upstream product

• 784-62-3 1-thioflavone 
• 141-52-6 sodium ethanolate 
• 934-87-2 S-phenyl thioacetate 
• 2142-69-0 2-bromophenyl methyl ketone 
• 623-51-8 ethyl 2-sulfanylacetate 
• 2634-33-5 1,2-benzisothiazolin-3-one 
• 127-08-2 potassium acetate 
• 108-24-7 acetic anhydride 
• 130826-24-3 S-(2-acetophenyl) benzothioate 
• 929083-19-2 1-[2-(1,1-dimethylethylsulfanyl)phenyl]ethanone 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 2142-70-3 2-iodoacetophenone 
• 22857-79-0 S-2-acetylphenyl N,N-dimethylcarbamothioate 
• 917-54-4 methyllithium 

Downstream Products

• 76256-33-2 bis-(2-acetyl-phenyl)-disulfide 
• 130826-24-3 S-(2-acetophenyl) benzothioate 
• 77175-58-7 2-<(4-chlorobenzyl)thio>acetophenone 
• 1441-97-0 2'-(methylthio)acetophenone 
• 167558-61-4 o-(Methoxymethylthio)acetophenone 
• 16854-67-4 4-hydroxythiocumarin 
• 1119040-30-0 (2S,3R,4S)-4-hydroxy-4-methyl-2-(4-nitrophenyl)-3,4-dihydro-2H-thiochromene-3-carbaldehyde 
• 1119040-12-8 (2S,3R,4S)-2-(4-chlorophenyl)-4-hydroxy-4-methyl-3,4-dihydro-2H-thiochromene-3-carbaldehyde 
• 1119040-15-1 (2S,3R,4S)-2-(4-bromophenyl)-4-hydroxy-4-methyl-3,4-dihydro-2H-thiochromene-3-carbaldehyde 
• 1119040-10-6 (2S,3R,4S)-4-(3-formyl-4-hydroxy-4-methyl-3,4-dihydro-2H-thiochromen-2-yl)benzonitrile 
• 1119040-06-0 (2S,3R,4S)-4-hydroxy-4-methyl-2-phenyl-3,4-dihydro-2H-thiochromene-3-carbaldehyde 
• 1119040-04-8 C₁₇H₁₄OS 
• 958301-24-1 1-[2-(1-phenylethylthio)phenyl]ethanone 

Relevant articles and documents

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Substituted Benzothietes: Synthesis and a Quantum Chemical Investigation of Their Cycloreversion Properties

A flexible synthesis for highly substituted benzothietes that does not require flash-vacuum pyrolysis was developed. This allows for the use of a number of functional groups and nonvaporizable molecules. Highly stabilized derivatives were isolated. The molecular orbital properties of various benzothietes were evaluated by density functional methods. The mechanism of the cycloreversion of the four-membered ring was compared to that of the oxygen-containing analogues.

SINGLE-STEP SYNTHESIS METHOD OF ARYL THIOL AND APPLICATION THEREOF

The present invention relates to a single-step synthesis method of aryl thiol, and more specifically, to a method of synthesizing aryl thiol in a single-step by making aryl halide react with alkane dithiol in the presence of a transition metal catalyst. According to the present invention, a single-step synthesis method using the transition metal catalyst, the synthesis method which is capable of synthesizing aryl thiol from aryl halide at a high yield, can be provided. Various aryl halides may be applied to the synthesis method. Further, the synthesis method has advantages that an easily usable reagent may be used, operations are simple, and reactions can be performed under mild conditions. In addition, the synthesized aryl thiol may be used in the synthesis of advanced molecules such as diaryl sulfides and benzothiophenes.COPYRIGHT KIPO 2017

Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa

We explore the chemical space of Pseudomonas quinolone signal analogs as privileged structures and report the discovery of a thioquinolone as a potent inhibitor of the important virulence factor elastase of the human pathogen Pseudomonas aeruginosa. We provide evidence that the derivative binds to the active site zinc of elastase and additionally acts as a fluorescent zinc sensor.

Copper(II)-Catalyzed Single-Step Synthesis of Aryl Thiols from Aryl Halides and 1,2-Ethanedithiol

A highly efficient transition metal-catalyzed single-step synthesis of aryl thiols from aryl halides has been developed employing copper(II) catalyst and 1,2-ethanedithiol. The key features are use of readily available reagents, a simple operation, and relatively mild reaction conditions. This new protocol shows a broad substrate scope with excellent functional group compatibility. A variety of aryl thiols are directly prepared from aryl halides in high yields. Furthermore, the aryl thiols are used in situ for the synthesis of more advanced molecules such as diaryl sulfides and benzothiophenes.

TMSI-Promoted vinylogous michael addition of siloxyfuran to 2-substituted chromones: A general approach for the total synthesis of chromanone lactone natural products

A concise and facile synthetic protocol for the construction of the 2-γ-lactone chromanone skeleton has been achieved through a TMSI-promoted diastereoselective vinylogous Michael addition of siloxyfuran to 2-substituted chromones. The applicability of this method is demonstrated through the rapid access to the total syntheses of (±)-microdiplodiasone, (±)-lachnone C, and (±)-gonytolides C and G.

CHROMAN - SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS

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Substituted 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b] thiophene derivatives as potent tubulin polymerization inhibitors

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COUMARIN-BASED COMPOUNDS

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