26824-02-2Relevant articles and documents
Loveridge et al.
, p. 221 (1971)
Substituted Benzothietes: Synthesis and a Quantum Chemical Investigation of Their Cycloreversion Properties
Ahlburg, Nils L.,Velarde, Andres R.,Kieber-Emmons, Matthew T.,Jones, Peter G.,Werz, Daniel B.
supporting information, p. 4255 - 4260 (2020/06/04)
A flexible synthesis for highly substituted benzothietes that does not require flash-vacuum pyrolysis was developed. This allows for the use of a number of functional groups and nonvaporizable molecules. Highly stabilized derivatives were isolated. The molecular orbital properties of various benzothietes were evaluated by density functional methods. The mechanism of the cycloreversion of the four-membered ring was compared to that of the oxygen-containing analogues.
Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa
Szamosvári, Dávid,Reichle, Valentin F.,Jureschi, Monica,B?ttcher, Thomas
supporting information, p. 13440 - 13443 (2016/11/19)
We explore the chemical space of Pseudomonas quinolone signal analogs as privileged structures and report the discovery of a thioquinolone as a potent inhibitor of the important virulence factor elastase of the human pathogen Pseudomonas aeruginosa. We provide evidence that the derivative binds to the active site zinc of elastase and additionally acts as a fluorescent zinc sensor.