35898-30-7

Basic information

• Product Name: 3',5'-DI-O-BENZOYLTHYMIDINE
• Synonyms: 3',5'-DI-O-BENZOYLTHYMIDINE;thymidine 3',5'-dibenzoate;3'-O,5'-O-Dibenzoylthymidine
• CAS NO: 35898-30-7
• Molecular Formula: C₂₄H₂₂N₂O₇
• Molecular Weight: 450.44
• EINECS: 252-786-1
• Mol File: 35898-30-7.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Density: 1.39 g/cm³
• CAS DataBase Reference: 3',5'-DI-O-BENZOYLTHYMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-DI-O-BENZOYLTHYMIDINE(35898-30-7)
• EPA Substance Registry System: 3',5'-DI-O-BENZOYLTHYMIDINE(35898-30-7)

Safety Data

• Hazardous Substances Data: 35898-30-7(Hazardous Substances Data)

Usage

General Description

3',5'-DI-O-BENZOYLTHYMIDINE is a chemical compound that consists of a thymidine molecule with two benzoate groups attached to the 3' and 5' positions. 3',5'-DI-O-BENZOYLTHYMIDINE is often used in organic synthesis and biochemistry research as a reagent or as a building block for the synthesis of nucleoside analogues. It is known for its potential antiviral and antitumor activities, and it has been studied for its ability to inhibit the growth of certain cancer cells. Additionally, 3',5'-DI-O-BENZOYLTHYMIDINE has been used as a substrate for enzymes involved in nucleoside metabolism, making it a valuable tool for studying nucleoside processing pathways in cells. Overall, this chemical compound has important applications in various areas of scientific research and pharmaceutical development.

Upstream product

• 175024-33-6 C₂₃H₂₉N₂O₇P 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 145828-13-3 α-D-1,3,5-tri-O-benzoyl-2-O-[3-(trifluoromethyl)benzoyl]ribofuranose 
• 51255-12-0 1-O-acetyl-3,5-di-O-benzoyl-2-deoxy-D-erythro-pentafuranose 
• 3444-09-5 1,3-bis(trimethylsilyl)thymine 
• 108647-88-7 ((2R,3S)-3-(benzoyloxy)-5-methoxytetrahydrofuran-2-yl)methyl benzoate 
• 95041-53-5 3,5-Di-O-benzoyl-2-desoxy-D-ribose 
• 65-71-4 thymin 
• 22224-41-5 1,3,5-tri-O-benzoyl-α-D-ribofuranoside 
• 50503-53-2 5-methyl-2,4-bis-trimethylsilanyloxy-pyridine 
• 303041-26-1 1-[3-(trifluoromethyl)benzoyl]-2,3,5-tribenzoyl-β-D-ribofuranose 
• 93-97-0 benzoic acid anhydride 
• 50-89-5 thymidine 
• 613-90-1 benzoyl cyanide 

Downstream Products

• 99680-04-3 C₃₀H₂₅ClN₂O₆S 
• 838-07-3 5-methyldeoxycytidine 
• 25406-44-4 N,5-dimethyl-2’-deoxycytidine 
• 123103-76-4 O^3'_,O5'-dibenzoyl-N⁴-hydroxy-5-methyl-2'-deoxy-cytidine 
• 50-89-5 thymidine 
• 59090-48-1 5-(azidomethyl)-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 
• 122567-96-8 Methanesulfonic acid (2R,3R,5R)-5-(5-methyl-2-oxo-4-thioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester 
• 122567-95-7 1-(5-O-trityl-2-deoxy-β-D-threo-pentofuranosyl)-4-thiothymine 
• 31615-99-3 3',5'-Di-O-benzoyl-2'-deoxyuridine 
• 7236-57-9 4-thiothymidine 
• 99692-47-4 1-[1-((2R,4S,5R)-4-Benzoyloxy-5-benzoyloxymethyl-tetrahydro-furan-2-yl)-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl]-3-methyl-3H-imidazol-1-ium; chloride 
• 137121-87-0 α/β-D-thymidine 
• 93841-35-1 O^3'_,O5'-dibenzoyl-4-thio-thymidine 

Relevant articles and documents

Photocycloaddition of benzoylated 2'-deoxyribonucleoside to 2,3-dimethyl-2-butene

The photochemical reactions of 3',5'-dibenzoyl-2'-deoxyuridine and -thymidine with 2,3-dimethyl-2-butene by upon ultraviolet (UV) irradiation in acetone have been investigated. Each reactant gave a pair of diastereomers in good yield. After recrystallization, mixed crystals of diastereomers could be isolated and purified. An X-ray analysis of a mixed crystal of the thymidine derivative (3b) showed a pair of diastereomers (A and B) composing a unit cell.

A general method for N-glycosylation of nucleobases promoted by (p-Tol)2SO/Tf2O with thioglycoside as donor

Based on a preactivation strategy using the (p-Tol)2SO/Tf2O system, a series of nucleosides were synthesized by coupling various thioglycosides with pyrimidines and purines under mild conditions. High yields and excellent β-stereoselectivities were obtained with either armed or disarmed N-glycosylation donors by tuning the amount of (p-Tol)2SO additive.

Continuous flow photocatalysis enhanced using an aluminum mirror: Rapid and selective synthesis of 2′-deoxy and 2′,3′-dideoxynucleosides

A unique photochemical flow reactor featuring quartz tubing, an aluminum mirror and temperature control has been developed for the photo-induced electron-transfer deoxygenation reaction to produce 2′-deoxy and 2′,3′-dideoxynucleosides. The continuous flow format significantly increased the efficiency and selectivity of the reaction.