51255-12-0

Usage

Uses

Used in Pharmaceutical Industry:
D-erythro-Pentofuranose, 2-deoxy-, 1-acetate 3,5-dibenzoate is used as a synthetic intermediate for the development of antiviral and anticancer research chemicals. Its chemical properties make it a promising candidate for creating new drugs that can effectively combat viral and cancerous diseases.
Used in Antiviral Applications:
In the field of antiviral research, D-erythro-Pentofuranose, 2-deoxy-, 1-acetate 3,5-dibenzoate is used as a key component in the synthesis of potential antiviral agents. Its incorporation into these agents can help in the development of drugs that can inhibit viral replication and reduce the severity of viral infections.
Used in Anticancer Applications:
D-erythro-Pentofuranose, 2-deoxy-, 1-acetate 3,5-dibenzoate is also utilized in the synthesis of anticancer research chemicals. Its role in the development of these chemicals can contribute to the creation of novel treatments that target and eliminate cancer cells, offering new hope for cancer patients.

InChI:InChI=1/C21H20O7/c1-14(22)26-19-12-17(28-21(24)16-10-6-3-7-11-16)18(27-19)13-25-20(23)15-8-4-2-5-9-15/h2-11,17-19H,12-13H2,1H3/t17-,18+,19?/m0/s1

Upstream product

• 95041-53-5 3,5-Di-O-benzoyl-2-desoxy-D-ribose 
• 108-24-7 acetic anhydride 
• 108647-88-7 ((2R,3S)-3-(benzoyloxy)-5-methoxytetrahydrofuran-2-yl)methyl benzoate 
• 112137-63-0 3,5-di-O-benzoyl-2-deoxy-D-ribofuranoside 
• 164145-69-1 1(S)-[(2R)-1,4-dioxaspiro[4.5]decanyl]-3-buten-1-ol 

Downstream Products

• 20963-97-7 C₂₃H₂₁N₃O₆ 
• 20838-22-6 C₂₄H₂₁N₅O₅ 
• 35898-30-7 C₂₄H₂₂N₂O₇ 
• 374627-80-2 1-(3,5-di-O-benzoyl-2-deoxy-β-D-erythro-pentofuranosyl)-5-isopropyl-4-(trifluoromethyl)-1H-pyrimidin-2-one 
• 137121-87-0 α/β-D-thymidine 
• 951-77-9 2'-Deoxycytidine 
• 3413-66-9 α-deoxyadenosine 
• 958-09-8 2'-deoxy-D-adenosine 
• 1343405-32-2 C₂₅H₁₈ClN₅O₅ 
• 10356-76-0 5-fluoro-2'-deoxycytidine 

Relevant academic research and scientific papers

Iron-Catalyzed Radical Cleavage/C?C Bond Formation of Acetal-Derived Alkylsilyl Peroxides

A novel radical-based approach for the iron-catalyzed selective cleavage of acetal-derived alkylsilyl peroxides, followed by the formation of a carbon–carbon bond is reported. The reaction proceeds under mild reaction conditions and exhibits a broad substrate scope with respect to the acetal moiety and the carbon electrophile. Mechanistic studies suggest that the present reaction proceeds through a free-radical process involving carbon radicals generated by the homolytic cleavage of a carbon–carbon bond within the acetal moiety. A synthetic application of this method to sugar-derived alkylsilyl peroxides is also described.

A chiral template-driven synthesis of a 3′-deoxy-3′-18F-fluorothymidine precursor

An asymmetric synthesis of a 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) precursor has been developed wherein the deoxysugar moiety was synthesized using a novel Ga-mediated allylation of (R)-2,3-cyclohexylideneglyceraldehyde as the key step. The synthesis deviates significantly from the previous syntheses of the 18F-FLT precursors wherein the expensive starting material, thymidine was used.

Synthesis of phosphonate analogues of 2-deoxyribose-1-phosphate

Phosphonate derivatives of 2-deoxyribose have been synthesized for the first time, by Lewis acid-mediated reaction of glycosyl donors with diisopropylhydroxymetylphosphonate for compounds 2 or with triisopropyl phosphite for compounds 3. Although, the selectivity of the reaction was moderate, in both cases the α-glycosides were predominantly obtained.

Improved procedure for the regiospecific synthesis of 2'-deoxyribonucleosides

2'-Deoxyribonucleosides are regiospecifically synthesized in high yields by catalyzing with KI-dibenzo-18-crown-6 PTC the condensation between unprotected silylated purines and pyrimidines and the appropriate easily available 2-deoxy-ribofuranosyl or pyranosyl sugar derivatives.