35929-26-1

Upstream product

• 72475-00-4 N,N-Bis(chlormethyl)propionamid 
• 71-43-2 benzene 
• 27374-25-0 [(1-Ethoxycyclopropyl)oxy]trimethylsilane 
• 143-33-9 sodium cyanide 
• 20455-68-9 N,N-dibenzylamine hydrochloride 
• 802294-64-0 propionic acid 
• 103-49-1 dibenzylamine 
• 74-85-1 ethene 
• 201230-82-2 carbon monoxide 
• 58288-30-5 N,N,N′,N′-tetrabenzylmethanediamine 
• 97-94-9 triethyl borane 
• 25370-09-6 dibenzylcarbamyl chloride 
• 79-03-8 propionyl chloride 

Downstream Products

• 321866-58-4 (2R,3R)-5-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2,3-dimethyl-5-oxo-pentanoic acid dibenzylamide 
• 22014-89-7 N,N-dibenzyl-N-(n-propyl)amine 
• 1262617-21-9 N,N-dibenzyl-N-(1-ethylcyclopropyl)amine hydrochloride 
• 103-49-1 dibenzylamine 
• 1598387-27-9 N,N-dibenzyl-3,3-difluoro-2-methyl-3-(trimethylsilyl)propanamide 
• 15429-13-7 N,N-dibenzyl-1-phenylpropan-1-amine 
• 858428-24-7 N,N-dibenzylbutan-2-amine 
• 6004-44-0 prop-1-en-1-one 
• 321866-63-1 [(1S,2S,3R)-3-Dibenzylcarbamoyl-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-2-methyl-butyl]-carbamic acid tert-butyl ester 
• 321866-62-0 (2R,3S,4S)-4-Azido-5-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2,3-dimethyl-5-oxo-pentanoic acid dibenzylamide 
• 321866-55-1 (2S,3S,4R)-2-tert-Butoxycarbonylamino-4-dibenzylcarbamoyl-3-methyl-pentanoic acid 
• 321866-64-2 (2S,3S,4R)-2-tert-Butoxycarbonylamino-4-dibenzylcarbamoyl-3-methyl-pentanoic acid methyl ester 
• 35952-50-2 N,N-Dibenzyl-3-hydroxy-2-methyl-3,3-diphenyl-propionamide 

Relevant academic research and scientific papers

A preparation method of the fatty amide

The invention discloses a preparation method for fatty acyl amide, belonging to the technical field of organic chemical synthesis. The method comprises the following steps: using substituted terminal olefin, carbon monoxide, and aminal or amine as raw materials, then carrying out catalyzation or co-catalyzation with aldehyde via a transition metal catalyst, and carrying out reaction in an organic solvent at 50 to 120 DEG C for 12 to 24 hours under the participation of a ligand or the co-participation of the ligand with an additive; removing the organic solvent when the reaction is completed, and carrying out column chromatography so as to obtain a fatty acyl amide compound. The preparation method for the fatty acyl amide has the following advantages: the raw materials, the catalyst and the additive for the reaction are cheap and easily available; synthetic process is simple; synthetic cost is greatly reduced; reaction conditions are mild; industrialization is easily realized; the raw materials and the catalyst for the reaction are clean and non-toxic and has small pollution to the environment.

Palladium-catalyzed hydroaminocarbonylation of alkenes with amines promoted by weak acid

The weak acid has been identified as an efficient basicity-mask to overcome the basicity barrier imparted by aliphatic amines in the Pd-catalyzed hydroaminocarbonylation, which enables both aromatic and aliphatic amines to be applicable in the palladium-catalyzed hydroaminocarbonylation reaction. Notably, by using this protocol, the marketed herbicide of Propanil and drug of Fentanyl could be easily obtained in a one-pot manner.

Palladium-catalyzed hydroaminocarbonylation of alkenes with amines: A strategy to overcome the basicity barrier imparted by aliphatic amines

A novel and efficient palladium-catalyzed hydroaminocarbonylation of alkenes with aminals has been developed under mild reaction conditions, and allows the synthesis of a wide range of N-alkyl linear amides in good yields with high regioselectivity. On the basis of this method, a cooperative catalytic system operating by the synergistic combination of palladium, paraformaldehyde, and acid was established for promoting the hydroaminocarbonylation of alkenes with both aromatic and aliphatic amines, which do not react well under conventional palladium-catalyzed hydroaminocarbonylation. Back to basics: The basicity of aliphatic amines precludes their use in the palladium-catalyzed hydroaminocarbonylation. This issue was overcome by using aminals as surrogates of aliphatic amines. A cooperative catalytic system was discovered to operate by the synergistic combination of palladium, paraformaldehyde, and acid for promotion of the hydroaminocarbonylation of alkenes with both aromatic and aliphatic amines.

One-pot amidation of olefins through Pd-catalyzed coupling of alkylboranes and carbamoyl chlorides

(Chemical Equation Presented) A one-pot synthesis of C1- elongated amides starting from olefins and carbamoyl chlorides has been developed. Alkyl-boranes, generated by hydroboration of terminal olefins with 9-BBN-H, underwent smooth coupling with carbamoyl chlorides in the presence of palladium catalyst and Cs2CO3.

Copper-catalyzed oxidative desulfurization-oxygenation of thiocarbonyl compounds using molecular oxygen: An efficient method for the preparation of oxygen isotopically labeled carbonyl compounds

A novel copper-catalyzed oxidative desulfurization reaction of thiocarbonyl compounds, using molecular oxygen as an oxidant and leading to formation of carbonyl compounds, has been developed, and the utility of the process is demonstrated by its application to the preparation of a carbonyl-18O labeled sialic acid derivative. The Royal Society of Chemistry.

Progress toward the total synthesis of callipeltin A (I): Asymmetric synthesis of (3S,4R)-3,4-dimethylglutamine

(equation presented) During the total synthesis of the novel cyclic depsipeptide callipeltin A (1), the unit (3S,4R)-3,4-dimethylglutamine, was successfully synthesized by asymmetric Michael addition and subsequent electrophilic azidation. The key feature of this approach is the generation of three adjacent stereogenic centers using the same camphorsultam chiral auxiliary.

A new and convenient synthesis of 1-aminocyclopropanecarboxylic acid from cyclopropanone acetal

Cyclopropanone acetal 2a undergoes the one-pot Strecker synthesis under sonication to provide the amino nitrile 8, which after hydrolysis and catalytic hydrogenolysis, gives 1-aminocyclopropanecarboxylic acid (ACC, 1) in good overall yield.