91089-40-6Relevant academic research and scientific papers
Efficient synthesis and biological evaluation of 4-arylcoumarin derivatives
Sun, Jie,Ding, Wei Xian,Zhang, Ke Yun,Zou, Yong
, p. 667 - 670 (2011)
Two bioactive natural 4-arylcoumarins, 5,7,4′-trimethoxy-4- phenylcoumarin (1a), 5,7-dimethoxy-4-phenylcoumarin (1b) and five closely related derivatives 1c-g were synthesized. In vitro evaluation with a catechol subunit for antioxidant and antimicrobial activity, these compounds using standard methods showed that compounds 1d, 1f displayed promise radical scavenging activity and 1f was found to be the most active one against Bacillus dysenteriae.
Aziridines as intermediates in diversity-oriented syntheses of alkaloids
Taylor, Alexander M.,Schreiber, Stuart L.
supporting information; experimental part, p. 3230 - 3233 (2009/08/17)
The efficient synthesis of small molecules that collectively comprise optimal small-molecule screening collections is an important goal. With this in mind, we have used N-alkyl aziridines in a regio- and stereochemically controlled synthesis of polycyclic
Intramolecular Nozaki-Hiyama-Kishi reactions and Ln(III)-catalyzed allylic rearrangement as the key steps towards 10-membered ring enediynes
Dai, Wei-Min,Wu, Anxin,Hamaguchi, Wataru
, p. 4211 - 4214 (2007/10/03)
A general and facile synthesis of the 3-substituted 10-membered ring enediynes 18-22 from the aldehydes 8 and 15 has been established by utilizing the intramolecular Nozaki-Hiyama-Kishi reaction and the lanthanide(III)-catalyzed rearrangement of allylic alkoxyacetates as the key steps. This work provides ready access to the (E)-3-acyloxy-4-(arylmethylidene)cyclodeca-1,5-diynes, which can be converted into the bioactive enediynes under physiological conditions.
