35976-99-9

Basic information

• Product Name: 3-(4-chlorobenzyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
• Synonyms: 3-(4-chlorobenzyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
• CAS NO: 35976-99-9
• Molecular Weight: 302.784
• Mol File: 35976-99-9.mol

Chemical Properties

• CAS DataBase Reference: 3-(4-chlorobenzyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorobenzyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one(35976-99-9)
• EPA Substance Registry System: 3-(4-chlorobenzyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one(35976-99-9)

Safety Data

• Hazardous Substances Data: 35976-99-9(Hazardous Substances Data)

Upstream product

• 118-48-9 isatoic anhydride 
• 103-72-0 phenyl isothiocyanate 
• 104-86-9 4-chlorobenzylamine 
• 333-20-0 potassium thioacyanate 
• 75-15-0 carbon disulfide 
• 794551-40-9 2-amino-N-(4-chlorobenzyl)benzamide 

Relevant articles and documents

A green and efficient synthesis of 2-thioxoquinazolinone derivatives in water using potassium thiocyanate

Green chemistry is one of the most important routes for the synthesis of heterocyclic compounds. In this regard, the synthesis of 2-thioxoquinazolinone derivatives was achieved by condensation of versatile materials including isatoic anhydride, amine and potassium thiocyanate in the green medium of water. This convenient and ef?cient method affords the desired products with good to excellent yields.

Convenient and sequential one-pot route for synthesis of 2-thioxoquinazolinone and quinazolinobenzothiazinedione derivatives

A new and efficient synthetic process has been developed for preparation of 2-thioxoquinazolinone and quinazolinobenzothiazinedione derivatives. The related products were synthesized through reaction of isatoic anhydride, amines/anthranilic acids, and carbon disulfide (CS2) in the presence of potassium hydroxide in ethanol at reflux. Graphical abstract: [Figure not available: see fulltext.]

KF/Al2O3 catalyzed one-pot three-component process for the synthesis of some 2-thioxoquinazolin-4(1h)-one derivatives

Three component one-pot reaction for synthesis of 2-thioxoquinazolin-4(1H)- ones are given by the condensation of isatoic anhydride, primary amine and phenyl isothiocyanate by using KF/Al2O3 as a environmentally friendly catalyst.