54773-19-2Relevant articles and documents
C?H Bond Trifluoromethylation of Arenes Enabled by a Robust, High-Valent Nickel(IV) Complex
D'Accriscio, Florian,Borja, Pilar,Saffon-Merceron, Nathalie,Fustier-Boutignon, Marie,Mézailles, Nicolas,Nebra, Noel
supporting information, p. 12898 - 12902 (2017/09/13)
The robust, high-valent NiIV complex [(Py)2NiIVF2(CF3)2] (Py=pyridine) was synthesized and fully characterized by NMR spectroscopy, X-ray diffraction, and elemental analysis. It reacts with aromatic compounds at 25 °C to form the corresponding benzotrifluorides in nearly quantitative yield. The monomeric and dimeric NiIIICF3 complexes 2?Py and 2 were identified as key intermediates, and their structures were unambiguously determined by EPR spectroscopy and X-ray diffraction. Preliminary kinetic studies in combination with the isolation of reaction intermediates confirmed that the C?H bond-breaking/C?CF3 bond-forming sequence can occur both at NiIVCF3 and NiIIICF3 centers.
Method for preparing halogenated 2-amino or 2-acetamido trifluoromethylbenzene derivatives
-
, (2008/06/13)
The halogenation of a compound of formula (1) or formula (2′), wherein Q is an NH2group optionally in the form of an addition salt, or an NHCOCH3group, and X is a halogen atom, using a compound of formula X2, in a solvent selected from an anhydrous halogenated hydrocarbon, a mixture of water and a halogenated hydrocarbon and optionally the compound of formula (1) itself, gives a 2-amino or 2-acetamido trifluoromethylbenzene halogenated in the 5 position of the benzene ring.