36043-49-9

Usage

Uses

Used in Organic Synthesis:
2-aminophenanthrene-9,10-dione is utilized as a key intermediate in the synthesis of a variety of organic compounds. Its unique structure allows for the creation of new molecules with diverse properties, which can be tailored for specific applications in the chemical industry.
Used in Dye Production:
In the dye industry, 2-aminophenanthrene-9,10-dione serves as a precursor for the production of dyes. Its chemical properties contribute to the color and stability of the dyes, making it an essential component in the formulation of various colorants used in textiles, printing inks, and other applications.
Used in Materials Science:
2-aminophenanthrene-9,10-dione is employed in materials science for its potential to enhance the properties of certain materials. Its incorporation into polymers or other materials can improve characteristics such as conductivity, stability, or reactivity, depending on the specific application.
Used in Biochemistry:
In the field of biochemistry, 2-aminophenanthrene-9,10-dione may be used as a reagent or a component in the development of new biochemical assays or processes. Its chemical reactivity and structural features can be leveraged to interact with biological molecules or to facilitate specific biochemical reactions.
While the provided materials do not specify particular industries for the applications of 2-aminophenanthrene-9,10-dione, the general uses listed above can be adapted to various industries where organic synthesis, dye production, materials science, and biochemistry are relevant.

Upstream product

• 604-95-5 2-nitrophenanthrene-9,10-dione 
• 7647-01-0 hydrogenchloride 
• 861337-24-8 2-azido-phenanthrene-9,10-dione 
• 7664-93-9 sulfuric acid 
• 84-11-7 9,10-phenanthrenequinone 
• 7705-08-0 iron(III) chloride 

Downstream Products

• 121677-52-9 2-((Ξ)-2-amino-10-oxo-10H-[9]phenanthrylidene)-benzo[de]thiochromen-3-one 
• 861349-60-2 2-(2,4,6-trinitro-anilino)-phenanthrene-9,10-dione 
• 4733-06-6 N-(9,10-dioxo-9,10-dihydrophenanthren-2-yl)acetamide 
• 112273-09-3 dibenzo[a,c]phenazin-2-ylamine 
• 861798-82-5 2-(2,4-dinitro-anilino)-phenanthrene-9,10-dione 

Relevant academic research and scientific papers

Potent reversible inhibitors of the protein tyrosine phosphatase CD45

The cytosolic portion of CD45, a major transmembrane glycoprotein found on nucleated hematopoietic cells, contains protein tyrosine phosphatase activity and is critical for T-cell receptor-mediated T-cell activation. CD45 inhibitors could have utility in the treatment of autoimmune disorders and organ graft rejection. A number of 9,10-phenanthrenediones were identified that reversibly inhibited CD45-mediated p-nitrophenyl phosphate (pNPP) hydrolysis. Chemistry efforts around the 9,10-phenanthrenedione core led to the most potent inhibitors known to date. In a functional assay, the compounds were also potent inhibitors of T-cell receptor-ediated proliferation, with activities in the low micromolar range paralleling their enzyme inhibition. It was also discovered that the nature of modification to the phenanthrenedione pharmacophore could affect selectivity for CD45 over PTP1B (protein tyrosine phosphatase 1B) or vice versa.

COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING PTEN INHIBITORS

This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from sources of non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.

PTEN INHIBITORS

The therapeutic use of inhibitors of PTEN activity in the treatment of PTEN-mediated diseases, conditions, and injuries is disclosed.

Cd45 inhibitors

Substituted phenanthrene-9,10-diones in accord with structural diagram I, 1compositions thereof and methods for the use thereof, for the treatment of T cell mediated conditions such as autoimmune diseases and organ graft rejection. In compounds of the invention, R1 at each occurrence is independently selected from hydrogen, halogen, NH-tosyl, N-di-tosyl, NH2, NO2, NH—CO—R2, CO—NH—R2, Ar, (CH2)nCH(COOH)R3 COR3 and NHCOCH2CH(COOH)NHR4, where R2, R3 and R4 are a selected from a variety of substituted or unsubstituted alkyl and aryl groupstand oligopeptides.