36065-41-5

Basic information

• Product Name: 3-phenyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole
• Synonyms: 3-Phenyl-5,6-dihydroimidazo(2,1-b)thiazole; 3-Phenyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole; Imidazo[2,1-b]thiazole, 5,6-dihydro-3-phenyl-
• CAS NO: 36065-41-5
• Molecular Formula: C₁₁H₁₀N₂S
• Molecular Weight: 202.2755
• Mol File: 36065-41-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 354.8°C at 760 mmHg
• Flash Point: 168.4°C
• Density: 1.31g/cm³
• Vapor Pressure: 3.26E-05mmHg at 25°C
• Refractive Index: 1.712
• CAS DataBase Reference: 3-phenyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole(36065-41-5)
• EPA Substance Registry System: 3-phenyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole(36065-41-5)

Safety Data

• Hazardous Substances Data: 36065-41-5(Hazardous Substances Data)

Usage

General Description

3-phenyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole is a chemical compound that belongs to the class of imidazo-thiazole derivatives. It is a heterocyclic compound containing both imidazole and thiazole rings, with a phenyl group attached at the third position. 3-phenyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole has potential biological activities and is being studied for its pharmacological properties. It is synthesized through various chemical reactions and has applications in the field of medicinal chemistry, specifically in drug discovery and development. Studies have shown that it exhibits promising activities in inhibiting certain biological processes, making it an interesting target for further research and potential drug development.

Upstream product

• 96-45-7 N,N'-ethylenethiourea 
• 70-11-1 α-bromoacetophenone 
• 7257-94-5 1-phenyl-2-(p-tolylsulfonyloxy)ethanone 
• 59863-93-3 2-(2-oxo-2-phenyl-ethylsulfanyl)-4,5-dihydro-imidazole-1-carboxylic acid methyl ester 
• 60498-94-4 N-acetyl-phenacylmercaptoimidazoline 
• 98-86-2 acetophenone 
• 75697-89-1 3-phenyl-5,6-dihydroimidazo<2,1-b>thiazolium tosylate 
• 36103-96-5 3-phenyl-5,6-dihydroimidazo<2,1-b>thiazole hydrobromide 
• 32188-94-6 [4H,5H]-2-phenacylthio-2-imidazoline hydrobromide 

Downstream Products

• 55139-32-7 3-phenyl-7-(phenyl-thiocarbamoyl)-6,7-dihydro-5H-imidazo[2,1-b]thiazolium betaine 
• 55139-36-1 3-phenyl-7-phenylcarbamoyl-6,7-dihydro-5H-imidazo[2,1-b]thiazolium betaine 
• 75697-89-1 3-phenyl-5,6-dihydroimidazo<2,1-b>thiazolium tosylate 
• 75703-72-9 Toluene-4-sulfonate7-methyl-3-phenyl-5,6-dihydro-imidazo[2,1-b]thiazol-7-ium; 
• 139313-09-0 3-phenyl-7-<2-(4'-bromophenyl)-2-oxoethyl>-5,6-dihydroimidazo<2,1-b>thiazolium bromide 
• 117376-95-1 3-phenyl-7-(2-phenyl-2-oxoethyl)-5,6-dihydroimidazo<2,1-b>thiazolium bromide 
• 139313-10-3 3-phenyl-7-(2-ethoxy-2-oxoethyl)-5,6-dihydroimidazo<2,1-b>thiazolium bromide 
• 55139-36-1 5,6-dihydro-3-phenyl-7-imidazo<2,1-b>thiazolium-betaine 
• 139313-33-0 methyl (2Z,5Z)-6-<5-benzoyl-6,7-bis(methoxycarbonyl)-2,3-dihydro-1H-pyrrolo<1,2-a>imidazol-1-yl>-3-(methoxycarbonyl)-6-phenyl-4-thiahexa-2,5-dienoate 

Relevant articles and documents

Dramatic Acceleration of an Acyl Transfer-Initiated Cascade by Using Electron-Rich Amidine-Based Catalysts

A tandem rearrangement of α,β-unsaturated thioesters into tricyclic ene-lactones fails with conventional amidine-based catalysts, but becomes possible when their electron-rich analogs are employed. A highly diastereo- and enantioselective version of this process has been developed using H-PIP 1b, a chiral catalyst prepared over a decade ago, but never utilized since its disclosure.

Hypervalent iodine in synthesis 92. A facile synthesis of 3-substituted-5,6-dihydroimidazo[2,1-b]thiazoles by cyclocondensation of alkynyl(phenyl)iodonium salts and imidazolidine-2-thione

A simple method for the synthesis of 3-substituted 5,6-dihydroimidazo[2,1-b]thiazoles is achieved by cyclocondensation of alkynyl(phenyl)iodonium salts with imidazolidine-2-thione.

Hypervalent Iodine in the Synthesis of Bridgehead Heterocycles: Novel and Facile Syntheses of 3-Substituted-5,6-Dihydroimidazothiazoles and 3-Phenylthiazolobenzimidazole from Acetophenones using benzene

The synthesis of 3-substituted-5,6-dihydroimidazothiazoles 3a-f has been achieved by using a novel and facile method involving hypervalent iodine oxidation of acetophenones 1a-f with benzene, followed by the treatment of the