36065-41-5

Usage

Uses

Used in Medicinal Chemistry:
3-Phenyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole is used as a chemical compound in medicinal chemistry for its potential biological activities and pharmacological properties. Its unique structure and ability to inhibit certain biological processes make it an interesting target for further research and potential drug development.
Used in Drug Discovery and Development:
In the field of drug discovery and development, 3-phenyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole is utilized as a starting material or a key intermediate in the synthesis of new drugs. Its promising activities in inhibiting specific biological processes contribute to the development of novel therapeutic agents for various diseases and conditions.
Used in Pharmaceutical Industry:
3-Phenyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole is used in the pharmaceutical industry as a potential drug candidate due to its unique chemical structure and biological activities. Its potential applications in treating various diseases and conditions make it a valuable asset in the development of new medications and therapies.

Upstream product

• 75697-89-1 3-phenyl-5,6-dihydroimidazo<2,1-b>thiazolium tosylate 
• 96-45-7 N,N'-ethylenethiourea 
• 7257-94-5 1-phenyl-2-(p-tolylsulfonyloxy)ethanone 
• 59863-93-3 2-(2-oxo-2-phenyl-ethylsulfanyl)-4,5-dihydro-imidazole-1-carboxylic acid methyl ester 
• 60498-94-4 N-acetyl-phenacylmercaptoimidazoline 
• 98-86-2 acetophenone 
• 36103-96-5 3-phenyl-5,6-dihydroimidazo<2,1-b>thiazole hydrobromide 
• 32188-94-6 [4H,5H]-2-phenacylthio-2-imidazoline hydrobromide 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 55139-36-1 3-phenyl-7-phenylcarbamoyl-6,7-dihydro-5H-imidazo[2,1-b]thiazolium betaine 
• 55139-32-7 3-phenyl-7-(phenyl-thiocarbamoyl)-6,7-dihydro-5H-imidazo[2,1-b]thiazolium betaine 
• 55139-36-1 5,6-dihydro-3-phenyl-7-imidazo<2,1-b>thiazolium-betaine 
• 139313-10-3 3-phenyl-7-(2-ethoxy-2-oxoethyl)-5,6-dihydroimidazo<2,1-b>thiazolium bromide 
• 117376-95-1 3-phenyl-7-(2-phenyl-2-oxoethyl)-5,6-dihydroimidazo<2,1-b>thiazolium bromide 
• 139313-09-0 3-phenyl-7-<2-(4'-bromophenyl)-2-oxoethyl>-5,6-dihydroimidazo<2,1-b>thiazolium bromide 
• 75697-89-1 3-phenyl-5,6-dihydroimidazo<2,1-b>thiazolium tosylate 
• 75703-72-9 Toluene-4-sulfonate7-methyl-3-phenyl-5,6-dihydro-imidazo[2,1-b]thiazol-7-ium; 
• 139313-33-0 methyl (2Z,5Z)-6-<5-benzoyl-6,7-bis(methoxycarbonyl)-2,3-dihydro-1H-pyrrolo<1,2-a>imidazol-1-yl>-3-(methoxycarbonyl)-6-phenyl-4-thiahexa-2,5-dienoate 

Relevant academic research and scientific papers

Dramatic Acceleration of an Acyl Transfer-Initiated Cascade by Using Electron-Rich Amidine-Based Catalysts

A tandem rearrangement of α,β-unsaturated thioesters into tricyclic ene-lactones fails with conventional amidine-based catalysts, but becomes possible when their electron-rich analogs are employed. A highly diastereo- and enantioselective version of this process has been developed using H-PIP 1b, a chiral catalyst prepared over a decade ago, but never utilized since its disclosure.

Structure-activity relationship of dihydroimidazo-, dihydropyrimido, tetrahydrodiazepino-[2,1-b]-thiazoles, and -benzothiazoles as an acylation catalyst

Cyclic isothioureas 1, 2, 3, and 4 were synthesized through a four-step procedure from the corresponding ortho-bromoanilines 10 via Pd- or Cu-catalyzed cyclization-benzothiazole formation. Nonbenzo analogues 7, 8, and 9 were synthesized by a condensation reaction of cyclic thioureas 15 and α-bromoacetophenones 14. Investigations of the acylation reactions of 1-phenylethanol with acid anhydrides in the presence of these cyclic isothiourea catalysts revealed their structure-activity relationships. Remarkable electronic effects resulting from substituent(s) on a benzo or phenyl moiety and the influence of the size of the annulating ring were observed. Introduction of an electron-donating substituent(s) enhanced the reaction rate. A few substitution effects on chiral catalysts of type 3 and 7 were also studied.

Hypervalent iodine in synthesis 92. A facile synthesis of 3-substituted-5,6-dihydroimidazo[2,1-b]thiazoles by cyclocondensation of alkynyl(phenyl)iodonium salts and imidazolidine-2-thione

A simple method for the synthesis of 3-substituted 5,6-dihydroimidazo[2,1-b]thiazoles is achieved by cyclocondensation of alkynyl(phenyl)iodonium salts with imidazolidine-2-thione.

Solid state synthesis of 2-aroylbenzo[b]furans, 1,3-thiazoles and 3-aryl-5,6-dihydroimidazo[2,1-b][1,3]thiazoles from α-tosyloxyketones using microwave irradiation

The expeditious solventless syntheses of 2-aroylbenzo[e]furans, 1,3-thiazoles and 3-aryl-5,6-dihydroimidazo[2,1-b]-[1,3]thiazoles are described from readily accessible α-tosyloxyketones and mineral oxides in processes that are accelerated by exposure to m

Hypervalent Iodine in the Synthesis of Bridgehead Heterocycles: Novel and Facile Syntheses of 3-Substituted-5,6-Dihydroimidazothiazoles and 3-Phenylthiazolobenzimidazole from Acetophenones using benzene

The synthesis of 3-substituted-5,6-dihydroimidazothiazoles 3a-f has been achieved by using a novel and facile method involving hypervalent iodine oxidation of acetophenones 1a-f with benzene, followed by the treatment of the

REACTION MECHANISM AND STRUCTURE OF NEW HETEROCYCLES VIA 1,4-DIPOLAR CYCLOADDITION OF IMIDAZOTHIAZOLIUM-BETAINE

New heterocycles, (12RS,13SR)- and (12SR,13SR)-12-benzoyl-2,4-dioxo-1,3,9-triphenyl-6,7-dihydro-12H-thiazinoimidazotriazines (4a and 4b), were synthesized via 1,4-dipolar cycloaddition from 5,6-dihydro-3-phenyl-7-N-phenyl(carbam

7-Alkylation and 7-Sulphonylation of 5,6-Dihydroimidazolo-thiazoles

Reinvestigation of the alkylation of 3-phenyl-5,6-dihydroimidazolothiazole has shown that methylation occurs exclusively at the 7-position, and that the free base is readily solvolysed to a mixture of 1-methylimidazolidin-2-one, 1-methylimidazolidine-2-thione, and diphenacyl sulphide and disulphide. 3-Methyl-5,6-dihydroimidazolothiazole with methane- and arene-sulphonyl chlorides gave the corresponding 7-sulphonylthiazolium chlorides.On heating, these rearranged to 3-(2-chloroethyl)-4-methyl-3-aryl (or alkyl)sulphonylimido-2,3-dihydrothiazoles.The 7-(4-chlorophenylsulphonyl) derivative lost this substituent with aqueous base while concentrated aqueous ammonia attacked the 7a-position leading to a 3--2-imino-4-methyl-2,3-dihydrothiazole.