36089-71-1Relevant academic research and scientific papers
Selective water-soluble gelatinase inhibitor prodrugs
Gooyit, Major,Lee, Mijoon,Schroeder, Valerie A.,Ikejiri, Masahiro,Suckow, Mark A.,Mobashery, Shahriar,Chang, Mayland
scheme or table, p. 6676 - 6690 (2011/12/02)
SB-3CT (1), a selective and potent thiirane-based gelatinase inhibitor, is effective in animal models of cancer metastasis and stroke; however, it is limited by poor aqueous solubility and extensive metabolism. We addressed these issues by blocking the pr
INHIBITORS OF MATRIX METALLOPROTEINASES
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, (2008/06/13)
The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat conditions and diseases associated therewith.
