3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: Effect of 6,7-disubstitution on potency and tissue selectivity

DOI: 10.1021/jm0580050

Source and publish data:

Journal of Medicinal Chemistry p. 4990 - 5000 (2005)

Update date:2022-07-29

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Authors:

De Tullio, Pascal

Boverie, Stéphane

Becker, Bénédicte

Antoine, Marie-Hélène

Nguyen, Quynh-Anh

Francotte, Pierre

Counerotte, Stéphane

Sebille, Sophie

Pirotte, Bernard

Lebrun, Philippe

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Article abstract of DOI:10.1021/jm0580050

A series of 6,7-disubstituted 4H-1,2,4-benzothiadiazine 1,1-dioxides bearing a short alkylamino side chain in the 3-position were synthesized. These compounds were tested on rat pancreatic islets and on rat aorta rings. In vitro data indicated that in mos

Full text of DOI:10.1021/jm0580050

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