58149-89-6

Basic information

• Product Name: 1-(6-methoxy-1-naphthyl)ethan-1-one
• Synonyms: 1-(6-methoxy-1-naphthyl)ethan-1-one;1-(6-Methoxy-1-naphthalenyl)ethanone;Einecs 261-142-9;1-(6-methoxynaphthalen-1-yl)ethanone
• CAS NO: 58149-89-6
• Molecular Formula: C₁₃H₁₂O₂
• Molecular Weight: 200.23318
• EINECS: 261-142-9
• Mol File: 58149-89-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 343.4°Cat760mmHg
• Flash Point: 158.9°C
• Appearance: /
• Density: 1.118g/cm³
• Vapor Pressure: 7.04E-05mmHg at 25°C
• Refractive Index: 1.594
• CAS DataBase Reference: 1-(6-methoxy-1-naphthyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-methoxy-1-naphthyl)ethan-1-one(58149-89-6)
• EPA Substance Registry System: 1-(6-methoxy-1-naphthyl)ethan-1-one(58149-89-6)

Safety Data

• Hazardous Substances Data: 58149-89-6(Hazardous Substances Data)

Usage

General Description

1-(6-methoxy-1-naphthyl)ethan-1-one is a chemical compound with the molecular formula C13H12O2. It belongs to the class of organic compounds known as aromatic ketones. 1-(6-methoxy-1-naphthyl)ethan-1-one is derived from naphthalene, a polycyclic aromatic hydrocarbon, and contains a methoxy group at the 6-position of the naphthalene ring. It is commonly used in the production of fragrances, flavors, and perfumes due to its aromatic properties. Additionally, 1-(6-methoxy-1-naphthyl)ethan-1-one has potential applications in the pharmaceutical industry as a building block for the synthesis of various bioactive compounds. Overall, this chemical plays a significant role in the manufacturing of scented products and has potential therapeutic uses.

InChI:InChI=1/C13H12O2/c1-9(14)12-5-3-4-10-8-11(15-2)6-7-13(10)12/h3-8H,1-2H3

Upstream product

• 36112-61-5 6-methoxy-1-naphthoic acid 
• 35227-78-2 diethyl (ethoxymagnesio)malonate 
• 917-54-4 methyllithium 
• 83669-11-8 1-(6-methoxy-3,4-dihydronaphthalen-1-yl)ethanone 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 2437-17-4 6-hydroxy-1-naphthoic acid 
• 61109-48-6 6-methoxy-1-naphthalenecarboxylic acid methyl ester 
• 93-04-9 2-Methoxynaphthalene 
• 108-24-7 acetic anhydride 
• 100-66-3 methoxybenzene 
• 88-14-2 2-furanoic acid 
• 77029-01-7 6-methoxy-[1]naphthonitrile 
• 6398-50-1 6-methoxy-3,4-dihydronaphthalene-1-carbonitrile 
• 5309-18-2 1,7-dimethoxynaphthalene 

Downstream Products

• 77029-02-8 2-(6-methoxy-1-naphthyl)-1-phenyl-2-propanol 

Relevant articles and documents

Development of new highly potent imidazo[1,2-b[pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1

Using a structure-based design approach, we have developed a new series of imidazo[1,2-b]pyridazines, targeting the calcium-dependent protein kinase-1 (CDPK1) from Toxoplasma gondii. Twenty derivatives were thus synthesized. Structure-activity relationships and docking studies confirmed the binding mode of these inhibitors within the ATP binding pocket of TgCDPK1. Two lead compounds (16a and 16f) were then identified, which were able to block TgCDPK1 enzymatic activity at low nanomolar concentrations, with a good selectivity profile against a panel of mammalian kinases. The potential of these inhibitors was confirmed in vitro on T. gondii growth, with EC50 values of 100 nM and 70 nM, respectively. These best candidates also displayed low toxicity to mammalian cells and were selected for further in vivo investigations on murine model of acute toxoplasmosis.

Asymmetric transfer hydrogenation of 1-naphthyl ketones by an ansa-Ru(II) complex of a DPEN-SO2N(Me)-(CH2)2(η 6-p-tol) combined ligand

The first second-generation designer Ru(II) catalyst 1b featuring an enantiopure N,C-(N-ethylene-N-methyl-sulfamoyl)-tethered (DPEN- κ2N,N′)/η6-toluene hybrid ligand is introduced. Using an S/C = 1000 in HCO2H-Et3N 5:2 transfer hydrogenation medium, secondary 1-naphthyl alcohols are obtained in up to >99.9% ee under mild conditions. Mechanistic factors are discussed.

APPLICATION OF METAL-LIQUID AMMONIA REDUCTION IN PREPARATION OF SYNTHONS FOR TOTAL SYNTHESIS OF STEROIDS

-