361160-40-9

Upstream product

• 504-29-0 2-aminopyridine 
• 99-90-1 para-bromoacetophenone 
• 882-33-7 diphenyldisulfane 
• 34658-66-7 2-(4-bromophenyl)imidazo[1,2-a]pyridine 
• 108-86-1 bromobenzene 
• 1483-72-3 diphenyliodonium chloride 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 1212-08-4 S-Phenyl benzenethiosulfonate 
• 98-80-6 phenylboronic acid 

Relevant academic research and scientific papers

Copper-catalyzed three-component reaction of imidazo[1,2-a]pyridine with elemental sulfur and arylboronic acid to produce sulfenylimidazo[1,2-a]pyridines

In this work, an efficient copper-catalyzed three-component reaction for the synthesis of sulfenylimidazo[1,2-a]pyridines using elemental sulfur as the sulfenylating agents has been developed. The reaction could proceed smoothly with a high degree of functional group tolerance and provide the desired products in moderate to good yield.

C3 Sulfenylation of N-Heteroarenes in Water under Catalyst-Free Conditions

A method for the catalyst-free C–H sulfenylation of imidazo[1,2-a]pyridines by using sulfonothioates as an odorless thioarylated reagent in aqueous medium was developed. This protocol was used for a variety of substituted imidazo[1,2-a]pyridines with broad functional-group tolerance and was extended to the sulfenylation of indoles and imidazothiazoles. The sulfonothioates were activated exclusively in aqueous medium rather than in an organic solvent, and the feasibility of the process for scale-up studies was demonstrated.

Copper-Catalyzed Three-Component System for Arylsulfenylation of Imidazopyridines with Elemental Sulfur

A one-pot three-component reaction for the regioselective synthesis of thioarylated imidazoheterocycles from aryl halides and elemental sulfur using copper(I) iodide as a catalyst has been developed. Reactions proceed with high efficiency and afford thioarylated imidazoheterocycles in good yields with broad functional group tolerance.

Cs2CO3 promoted direct C-H bond sulfenylation of imidazo[1,2-a]pyridines and related heteroarenes in ionic liquid

An efficient and novel method was developed for the synthesis of 3-sulfenyl imidazo[1,2-a]pyridines in good to excellent yields via a Cs2CO 3 promoted direct sulfenylation of imidazo[1,2-a]pyridines. The reaction proceeds smoothly with a wide range of structurally diverse heteroarenes and disulfides. This protocol is environmentally friendly because it is free of transition-metal catalysts and utilizes aryl-substituted imidazolium-based ionic liquid rather than volatile organic solvents.

Aerobic multicomponent tandem synthesis of 3-sulfenylimidazo[1,2-a] pyridines from ketones, 2-aminopyridines, and disulfides

An aerobic CeCl3·7H2O/NaI-catalyzed C-H functionalization reaction was developed for the synthesis of 3-sulfenylimidazo[1,2-a]pyridines from easily available ketones, 2-aminopyridines, and disulfides without DMSO or peroxide as an ox