36132-95-3

Usage

Uses

Used in Chemical Synthesis Industry:
4-Methoxy-1,2-benzenedimethanol is used as a key intermediate in the synthesis of various organic compounds for [application reason]. Its unique structure with a phenol group, methoxy group, and two hydroxymethyl groups allows for versatile chemical reactions and the formation of a wide range of products.
Used in Pharmaceutical Industry:
4-Methoxy-1,2-benzenedimethanol is used as a building block in the development of pharmaceutical compounds for [application reason]. Its functional groups can be utilized to create new drug molecules with potential therapeutic properties.
Used in Flavor and Fragrance Industry:
4-Methoxy-1,2-benzenedimethanol is used as a starting material in the production of flavor and fragrance compounds for [application reason]. Its aromatic structure can contribute to the creation of unique scents and tastes in various consumer products.
Used in Dye and Pigment Industry:
4-Methoxy-1,2-benzenedimethanol is used as a precursor in the synthesis of dyes and pigments for [application reason]. Its ability to form colored compounds makes it a valuable component in the production of various colorants for industrial applications.

InChI:InChI=1/C9H12O3/c1-12-9-3-2-7(5-10)8(4-9)6-11/h2-4,10-11H,5-6H2,1H3

Upstream product

• 1885-13-8 4-methoxyphthalic acid 
• 28281-76-7 5-methoxyisobenzofuran-1,3-dione 
• 4741-62-2 5-methoxyisobenzofuran-1(3H)-one 
• 99-06-9 3-Carboxyphenol 
• 50-00-0 formaldehyd 
• 586-38-9 3-Methoxybenzoic acid 
• 22479-95-4 dimethyl 4-hydroxyphthalate 

Downstream Products

• 4685-45-4 1,2-bischloromethyl-4-methoxybenzene 
• 1333428-89-9 2-methoxy-6-nitronaphthalen-7-yl-methyl 2-(benzamido)acetate 
• 6500-51-2 4-methoxybenzene-1,2-dicarbaldehyde 
• 36132-97-5 4-methoxy-1,2-benzenediacetonitrile 
• 36132-96-4 1,2-bis(bromomethyl)-4-methoxybenzene 
• 4741-63-3 6-methoxyphthalide 
• 4741-62-2 5-methoxyisobenzofuran-1(3H)-one 

Relevant academic research and scientific papers

IDO/TDO Inhibitor

A compound of formula (I) given below or a pharmaceutically acceptable salt of the compound is useful as an IDO/TDO inhibitor. Thus, the compound of formula (I) or the pharmaceutically acceptable salt of the compound can be used as, for example, a therapeutic agent for a disease or a disorder selected from tumor, infectious disease, neurodegenerative disorder, cataract, organ transplant rejection, autoimmune disease, postoperative cognitive impairment, and disease related to women's reproductive health [in the following formula (I), ring A represents an aromatic ring, an aliphatic ring, a heterocyclic ring, or a condensed ring of two or more rings selected from an aromatic ring, an aliphatic ring and a heterocyclic ring; X, R1 and R2 represent a substituent on a ring atom constituting ring A; m represents an integer of 0 to 6; X represents, for example, a halogen atom; and R1 and R2 are the same or different and are selected from, for example, the group consisting of groups of formula (a) or formula (b); and in the following formula (a) and formula (b), Y is selected from the group consisting of O, S, and Se, Z is selected from the group consisting of O, S, and Se, n represents an integer of 1 to 8, r represents an integer of 1 to 8, s represents an integer of 1 to 8, R4 represents, for example, —C(═NH)—HN2, and R6 represents, for example, a substituted or unsubstituted aryl group].

Site-Selective Functionalization of (sp3)C?H Bonds Catalyzed by Artificial Metalloenzymes Containing an Iridium-Porphyrin Cofactor

The selective functionalization of one C?H bond over others in nearly identical steric and electronic environments can facilitate the construction of complex molecules. We report site-selective functionalizations of C?H bonds, differentiated solely by rem

Synthesis of 1,2-phenylenedimethanols by base-promoted reduction of isobenzofuran-1(3H)-ones with silane

An efficient method for preparation of substituted 1,2-phenylenedimethanols and aliphatic 1,4-diols that are valuable intermediates in organic synthesis, has been developed by the base-promoted reduction of isobenzofuran-1(3H)-ones and γ-lactones with silane under mild conditions. Compared with traditional procedures using stoichiometric amounts of metal hydrides and alkyl reductants, the present method avoids the use of sensitive reagents and is operationally simple and a broad variety of functional groups are tolerated.

Catalytic Electrophilic Alkylation of p-Quinones through a Redox Chain Reaction

Allylation and benzylation of p-quinones was achieved through an unusual redox chain reaction. Mechanistic studies suggest that the existence of trace hydroquinone initiates a redox chain reaction that consists of a Lewis acid catalyzed Friedel–Crafts alkylation and a subsequent redox equilibrium that regenerates hydroquinone. The electrophiles could be various allylic and benzylic esters. The addition of Hantzsch ester as an initiator improves the efficiency of the reaction.

Synthesis of benzobicycloheptanones via the trap of photogenerated ketene methide intermediate with olefins

Irradiation of ortho-formyl dienes with UV light led to benzobicycloheptanones in high yields and chemoselectivities via a photogenerated ketene methide/Diels-Alder cascade reaction. The reaction mechanism was proposed to be a [1,5]-H shift process rather than a radical pathway based on control experiments. DFT calculations indicate that the energy of transition states is responsible for the high chemoselectivity observed in this protocol.

7-Methoxy-3-nitro-2-naphthalenemethanol - A new phototrigger for caging applications

Synthesis, photochemistry and photorelease properties of 7-methoxy-3-nitro-2-naphthalenemethanol (MNNM) are described. Photoirradiation (≥370 nm) of MNNM covalently linked to hippuric acid causes efficient release (～90%) of hippuric acid.

Photoexcited proton transfer from enhanced photoacids

Naphthols with electron-withdrawing groups such as cyano or methanesulfonyl at C-5 and C-8 exhibit greatly enhanced photoacidity. This increase in photoacidity enables the substituted naphthols to undergo excited-state proton transfer (ESPT) in alcohols and Me2SO in the absence of water. In aqueous tetrahydrofuran solution, efficient proton transfer to water occurs at much lower water concentrations than with the parent naphthol, and the kinetics of proton transfer indicate that a smaller water cluster is involved.

A synthesis of two novel benzo[f]ninhydrin analogs: 6-methoxybenzo[f]ninhydrin and thieno[f]ninhydrin

Improved methodology for the synthesis of benzo[f]ninhydrin (1) is described. The generality of this approach is illustrated with the synthesis of two novel analogs, 6-methoxybenzo[f]ninhydrin (3) and thieno[f]ninhydrin (4).

2-[2H-(1,3-dihydroisoindole)alkylene]-4,5-dihydroimidazoles and pharmaceutical compositions thereof

A compound of formula (I): STR1 or a pharmaceutically acceptable salt, ester or amide thereof, wherein: Z represents a residue of a substituted or unsubstituted aryl group, X represents O or NRo wherein Ro represents a hydrogen atom,