3617-46-7

Usage

InChI:InChI=1/C22H24N2O7/c25-19(26)12-11-17(21(28)29)23-20(27)18(13-15-7-3-1-4-8-15)24-22(30)31-14-16-9-5-2-6-10-16/h1-10,17-18H,11-14H2,(H,23,27)(H,24,30)(H,25,26)(H,28,29)/t17-,18-/m0/s1

Upstream product

• 56-86-0 L-glutamic acid 
• 1161-13-3 N-Cbz-L-Phe 
• 133464-46-7 (S)-2-[((9H-fluoren-9-yl)methoxy)carbonylamino]-5-(allyloxy)-5-oxopentanoic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 109453-49-8 (C₈H₇O₂)(NHCHCOO)(CH₂C₆H₅)(CO₂C₂H₅) 
• 52641-32-4 N-benzyloxycarbonyl-L-phenylalanyl chloride 
• 16450-41-2 L-glutamic acid diethyl ester 
• 2578-84-9 N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester 
• 3617-43-4 N-(N-benzyloxycarbonyl-L-phenylalanyl)-L-glutamic acid diethyl ester 
• 2448-45-5 Cbz-D-Phe 
• 187458-77-1 L-glutamic acid methyl ester hydrochloride 

Downstream Products

• 3617-45-6 N-phenylalanyl-glutamic acid 

Relevant academic research and scientific papers

Convenient green preparation of dipeptides using unprotected α-amino acids

Dipeptides and amides were obtained in high yields from N-carbobenzyloxy α-amino acids and 3-phenylpropanoic acid with unprotected α-amino acids via the corresponding mixed carbonic carboxylic anhydrides using ethyl chloroformate and triethylamine by an ecological and convenient method in which the protection of C-terminals is not needed.

Ecological base-conditioned preparation of dipeptides using unprotected α-amino acids containing hydrophilic side chains

The coupling reactions of 3-phenylpropanoic acid and Ncarboxybenzyl á-amino acids with unprotected á-amino acids containing hydrophilic side chains such as aliphatic alcohol, aromatic alcohol, thiol, carboxylic acid, and amide afforded the corresponding amides in 6696% yield without racemization via the corresponding mixed carbonic carboxylic anhydrides under basic conditions through an ecological green synthetic method.

Synthesis and Kinetic Characterisation of Water-Soluble Fluorogenic Acyl Donors for Transglutaminase 2

Small glutamate-containing peptides bearing coumarin derivatives as fluorescent leaving groups attached to the γ-carboxylic acid group of the Glu residue were synthesised and investigated with regard to their potential to act as substrates for transglutam

Convenient peptide synthesis using unprotected α-amino acids containing another hydrophilic moiety under basic conditions

Carboxylic acids 1 and 7 reacted effectively with unprotected α-amino acids 2 containing another hydrophilic moiety under basic conditions via activation by ethyl chloroformate and triethylamine to afford the corresponding amides in 7499% yields.

Convenient peptide synthesis without protection of C-Terminals

Condensation of carboxylic acids 1 and 5 with unprotected α-amino acids 2 via activation by ethyl chloroformate and triethylamine proceeded effectively to afford the corresponding amides in 5099% yields. Tripeptide 7c was obtained in 42% yield from the dipeptide 6c in a similar manner.