36171-50-3Relevant academic research and scientific papers
Potassium-Zincate-Catalyzed Benzylic C?H Bond Addition of Diarylmethanes to Styrenes
Liu, Yu-Feng,Zhai, Dan-Dan,Zhang, Xiang-Yu,Guan, Bing-Tao
supporting information, p. 8245 - 8249 (2018/02/26)
Direct functionalization of the benzylic C?H bond of diarylmethanes is an important strategy for the synthesis of diarylmethine-containing compounds. However, the methods developed to date for this purpose require a stoichiometric amount (usually more) of either a strong base or an oxidant. Reported here is the first catalytic benzylic C?H bond addition of diarylmethanes to styrenes and conjugated dienes. A potassium zincate complex, generated from potassium benzyl and zinc amide, acts as a catalyst and displays good activity and chemoselectivity. Considering the atom economy of the reaction and the ready availability of the catalyst, this reaction constitutes a practical, efficient method for diarylalkane synthesis.
KOtBu-Promoted Oxidation of (Hetero)benzylic Csp3-H to Ketones with Molecular Oxygen
Wang, Huiqiao,Wang, Zhong,Huang, Hongchun,Tan, Jiajing,Xu, Kun
supporting information, p. 5680 - 5683 (2016/11/17)
An efficient and practical (hetero)benzylic sp3 C-H oxidation method has been developed. Notably, this user-friendly protocol employs inexpensive potassium tert-butoxide (KOtBu) as a promoter and proceeds under mild conditions using oxygen as the oxidant. A large variety of oxidation products were prepared in good to excellent yields. The utility of this "green" methodology was further demonstrated by the scale-up preparation of a biologically valued molecule.
