3619-88-3Relevant academic research and scientific papers
Ni-Catalyzed Asymmetric Hydrophosphination of Unactivated Alkynes
Gao, Li,Han, Xue-Yu,Huang, Zhuo,Liu, Xu-Teng,Sun, Ying-Ying,Wu, Yue,Zhang, Qing-Wei
supporting information, p. 11309 - 11316 (2021/08/03)
The practical synthesis of P-stereogenic tertiary phosphines, which have wide applications in asymmetric catalysis, materials, and pharmaceutical chemistry, represents a significant challenge. A regio- and enantioselective hydrophosphination using cheap a
Intermolecular zirconium-catalyzed hydrophosphination of alkenes and dienes with primary phosphines
Ghebreab, Michael B.,Bange, Christine A.,Waterman, Rory
supporting information, p. 9240 - 9243 (2014/07/21)
Catalytic hydrophosphination of terminal alkenes and dienes with primary phosphines (RPH2; R = Cy, Ph) under mild conditions has been demonstrated using a zirconium complex, [κ5-N,N,N,N,C-(Me 3SiNCH2CH2)2NCH2CH 2NSiMe2CH]Zr (1). Exclusively anti-Markovnikov functionalized products were observed, and the catalysis is selective for either the secondary or tertiary phosphine (i.e., double hydrophosphination) products, depending on reaction conditions. The utility of the secondary phosphine products as substrates for further elaboration was demonstrated with a platinum-catalyzed asymmetric alkylation reaction.
A straightforward synthesis of unsymmetrical secondary phosphine boranes
Petit, Christelle,Favre-Reguillon, Alain,Mignani, Gerard,Lemaire, Marc
, p. 326 - 330 (2011/03/18)
A one-pot procedure for the synthesis of unsymmetrical alkyl-substituted secondary phosphine oxides is described. The sequential addition of N-benzylaniline to a solution of dichlorophenylphosphine and 1-methylimidazole in methylcyclohexane, separating of the protic ionic liquid formed, addition of Grignard reagent followed by hydrolysis gave unsymmetrical secondary phosphine oxides (SPOs) in high yield. The use of ionic liquids in the first step is essential and streamlined the synthesis. Unsymmetrical SPOs could be quantitatively reduced to secondary phosphine using a catalytic amount of Ti(OiPr)4 and tetramethyldisiloxane (TMDS) under mild reaction conditions.
High atom-economical one-pot synthesis of secondary phosphines and their borane complexes using recycling phosphorus donor reagent
Baccolini, Graziano,Boga, Carla,Mazzacurati, Marzia,Sangirardi, Federico
, p. 1677 - 1680 (2007/10/03)
A general new method for the one-pot preparation of secondary phosphines 11 and in situ generation of their borane complexes 12 is described. This method consists of the sequential addition, at room temperature, of equivalent amounts of R1MgBr and R2MgBr to 1 equiv of the phosphorus atom donor reagent 1. Final treatment with water gives secondary phosphines R 1R2PH (or the corresponding phosphine-borane complexes if treated with BH3·THF) and the end product 6, which can be recycled.
ZUR REAKTION VON PHOSPHORVERBINDUNGEN MIT SCHWESINGER BASEN-I P-C-BINDUNGKNUEPFUNG AN P-H-FUNKTIONELLEN PHOSPHORVERBINDUNGEN
Uhlig, Frank,Puschner, Beatrix,Herrmann, Eckhard,Zobel, Bernhard,Bernhardt, Henry,Uhlig, Wolfram
, p. 155 - 164 (2007/10/02)
Secondary and tertiary phosphines (RR'PH; R2R'P) may be synthesized by alkylation of primary or secondary phosphines with organo halides (R' = Et, n-C7H15, Bz, Me3Si; X = Cl, Br) in the presence of Schwesinger bases as auxillary bases in high yields.Alkylation of diphenylphosphine with alkylene dihalides and Schwesinger bases affords alkylendiphosphines. Key words: Alkylation; secondary and tertiary phosphines; Schwesinger bases.
A Simple Synthesis and Some Synthetic Applications of Substituted Phosphide and Phosphinite Anions
Tsvetkov, E. N.,Bondarenko, N. A.,Malakhova, I. G.,Kabachnik, M. I.
, p. 198 - 208 (2007/10/02)
Based on data for the acidity relationship of phosphines and phosphinous acids and water in dimethyl sulfoxide and water, a simple method is reported for the generation of phosphide and phosphinite anions by the action of concentrated aqueous alkali on primary and secondary phosphines as well as phosphinous acids in dimethyl sulfoxide or other dipolar aprotic solvents.Alkylation of the anion yields secondary and tertiary phosphines, polyphosphines, functionally substituted phosphines as well as similarly substituted phosphine oxides.Phosphinous acids have beenalkylated in various solvents in two-phase systems containing concentrated aqueous alkali and tetrabutylammonium iodide as phase transfer catalyst.
