36200-47-2Relevant academic research and scientific papers
Triazoliptycenes: A Twist on Iptycene Chemistry for Regioselective Cross-Coupling to Build Nonstacking Fluorophores
Kang, Taewon,Kim, Hongsik,Lee, Dongwhan
supporting information, p. 6380 - 6383 (2017/12/08)
Triazoliptycene fluorophores have been designed and synthesized, in which a three-dimensional propeller-like iptycene motif is employed to suppress intermolecular π-π stacking in the solid state. Key to the success of this modular synthesis is a stereoelectronic bias imposed by the iptycene scaffold, which assists the desired regioselectivity in the C-N cross-coupling step as the last-stage structure diversification from a common precursor.
α,α-dibromoketones as useful precursors in organic synthesis: A simple and efficient synthesis of 2,4-diaryl- 1,2,3-triazoles via oxidative cyclization of bisphenylhydrazones
Arora, Loveena,Sharma, Nisha,Kapoor, Jitander K.
, p. 291 - 296 (2019/01/18)
α,α-Dibromoacetophenones (1a-1f) on reaction with phenylhydrazine afford corresponding arylglyoxal bisphenylhydrazones (2a-2f). The oxidation of bishydrazones 2a-2f by using copper(II) chloride in acetic acid leads to intramolecular cyclization with the formation of 2,4-diaryl-1,2,3-triazoles (3a-3f). The method for the conversion 1 → 3 has been simplified by developing one-pot procedure without isolation of intermediates 2.
Another way to the synthesis of 1,2,3-triazoles
Xu, Beihua,Hu, Yongzhou
, p. 1217 - 1222 (2013/10/21)
The reactions of α-bromoacetophenones with methylhydrazine in refluxing acetic acid generated 2-methyl-4-aryl-2H-[1,2,3]triazoles in good yields. The method was developed by the reactions of α-bromoacetophenones with phenylhydrazines in the presence of cu
1,2,3- and 1,2,4-triazolium salts, pyrazoles, and quinoxalines from diarylnitrilimines and isocyanides: A study of the scope
Moderhack, Dietrich,Daoud, Ali
, p. 625 - 637 (2007/10/03)
Formation of the four title compounds has been found to be strongly dependent on substituents: 1,2,3-Triazolium salts 6 do not arise from nitrilimines 2 that have an electron- acceptor attached to either the C- or the N-phenyl group. Likewise tert-butyl and aryl isocyanides do not afford this class of compounds; from the former isocyanide, dequaternization products 7 are obtained instead, whereas from the latter 1,2,4-triazolium salts 11 are formed. Compounds 11 with a tert-butyl group at the ring are unstable too, giving rise to triazoles 13. Pyrazole formation (analogues of 14) is completely suppressed when both tert-butyl and aryl isocyanides are used, whereas access to this ring system works best with sec-alkyl isocyanides (the influence of substituents of 2 being almost negligible in this case). Formation of quinoxalines 23 which arise from intermediary 1,2-diazets 22 by ring expansion is much favoured on employment of 2 that bears a donator substituent at the N-phenyl group, and under this premise ring closure to 22 is virtually independent on the nature of the isocyanide. Formation of 23 is not observed with 2 having acceptor groups.
Studies on the Hydrazine Derivatives of p-Tolylglyoxal
El Sadek, Mohamed M.
, p. 357 - 359 (2007/10/02)
A number of p-tolylglyoxalmono- and -bishydrazones were synthesized, acylated, and cyclized to the corresponding 1,2,3-triazoles.Some of the reactions of the prepared triazoles were carried out.Analyses and IR and UV spectra of the compounds prepared were recorded.
