3623-53-8

Basic information

• Product Name: neoisomenthol
• Synonyms: neoisomenthol
• CAS NO: 3623-53-8
• Molecular Weight: 156.268
• Mol File: 3623-53-8.mol
• Article Data: 28

Chemical Properties

• CAS DataBase Reference: neoisomenthol(CAS DataBase Reference)
• NIST Chemistry Reference: neoisomenthol(3623-53-8)
• EPA Substance Registry System: neoisomenthol(3623-53-8)

Safety Data

• Hazardous Substances Data: 3623-53-8(Hazardous Substances Data)

Upstream product

• 89-83-8 thymol 
• 5392-40-5 (E/Z)-3,7-dimethyl-2,6-octadienal 
• 106-23-0 3,7-dimethyl-oct-6-enal 
• 491-07-6 (+/-)-menthone 
• 555-31-7 aluminum isopropoxide 
• 89-81-6 piperitone 
• 1678-82-6 trans-1,4-menthane 
• 74497-15-7 (L) Ethyl 2-chloropropanoate 
• 89-78-1 menthol 
• 42411-39-2 (R)-ethyl 2-chloropropanoate 
• 611-70-1 phenyl isopropyl ketone 
• 2866-71-9 (1,1'-bicyclopentyl)-2-one 
• 535-13-7 2-chloro-propanoic acid, ethyl ester 
• 2385-77-5 (R)-Citronellal 

Downstream Products

• 57084-14-7 Dodecanoic acid (1R,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester 
• 42411-39-2 (R)-ethyl 2-chloropropanoate 
• 55284-69-0 (1R)-Menthyl (L)-2-chloropropanoate 
• 55284-69-0 (1S)-Menthyl (L)-2-chloropropanoate 
• 15356-70-4 menthol 
• 89-48-5 menthyl acetate 
• 89-48-5 neoisomenthyl acetate 
• 89-48-5 neomenthyl acetate 
• 907606-03-5 C₄₄H₅₄O₆ 
• 2216-54-8 rac-menthylamine 
• 27374-00-1 (1S,2S,5R)-1-(4-nitrobenzoyl)-2-(1-methylethyl)-5-methylcyclohexan-1-ol 
• 1144-50-9 (+/-)-Neomenthyl-acetoacetat 
• 80595-65-9 (2E,7E,9E)-11-Methyl-dodeca-2,7,9-trienoic acid (1R,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 80595-66-0 (2E,7E)-Deca-2,7,9-trienoic acid (1R,5R)-2-isopropyl-5-methyl-cyclohexyl ester 

Relevant articles and documents

Continuous synthesis of menthol from citronellal and citral over Ni-beta-zeolite-sepiolite composite catalyst

One-pot continuous synthesis of menthols both from citronellal and citral was investigated over 5 wt% Ni supported on H-Beta-38-sepiolite composite catalyst at 60–70 °C under 10–29 bar hydrogen pressure. A relatively high menthols yield of 53% and 49% and stereoselectivity to menthol of 71–76% and 72–74% were obtained from citronellal and citral respectively at the contact time 4.2 min, 70 °C and 20 bar. Citral conversion noticeably decreased with time-on-stream under 10 and 15 bar of hydrogen pressure accompanied by accumulation of citronellal, the primary hydrogenation product of citral, practically not affecting selectivity to menthol. A substantial amount of defuctionalization products observed during citral conversion, especially at the beginning of the reaction (ca. 1 h), indicated that all intermediates could contribute to formation of menthanes. Ni/H-Beta-38-sepiolite composite material prepared by extrusion was characterized by TEM, SEM, XPS, XRD, ICP-OES, N2 physisorption and FTIR techniques to perceive the interrelation between the physico-chemical and catalytic properties.

A synthetic process of L-menthol

The invention relates to the field of spice synthesis and particularly relates to a synthetic process of L-menthol. The process includes steps of d,l-menthol synthesizing, d,l-menthol rectification, d,l-menthol esterification, d,l-menthyl benzoate rectification, d,l-menthyl benzoate resolution, D-menthol synthesizing, menthol isomerization and L-menthol synthesizing. The process adopts thymol that is a simple, easily available and cheap chemical product as a raw material. Esterification conditions are optimized and the esterification and rectification are performed at the same time so as to allow the esterification to be converted into a way beneficial to d,l-menthyl benzoate production, thus increasing the esterification yield. Crystallization and resolution are optimized by utilization of the d,l-menthyl benzoate. Preparation of the L-menthol by the process is characterized by being high in yield, low in cost, simple and convenient in operation, suitable for continuous and large-scale production, and the like. According to the process, operation of the process is cyclic with a whole system being sealed, and the process is free of waste water, energy-saving and environmental friendly.

P450-catalyzed regio- and stereoselective oxidative hydroxylation of disubstituted cyclohexanes: Creation of three centers of chirality in a single CH-activation event This paper is dedicated to the memory of Harry H. Wasserman

Wild-type P450-BM3 is able to catalyze in a highly regio- and diastereoselective manner the oxidative hydroxylation of non-activated disubstituted cyclohexane derivatives lacking any functional groups, including cis- and trans-1,2-dimethylcyclohexane, cis- and trans-1,4-dimethylcyclohexane, and trans-1,4-methylisopropylcyclohexane. In all cases except chiral trans-1,2-dimethylcyclohexane as substrate, the single hydroxylation event at a methylene group induces desymmetrization with simultaneous creation of three centers of chirality. Certain mutants increase selectivity, setting the stage for future directed evolution work.