36244-10-7

Basic information

• Product Name: 4(3H)-Quinazolinone, 3-(4-methylphenyl)-2-(trifluoromethyl)-
• CAS NO: 36244-10-7
• Molecular Formula: C16H11F3N2O
• Molecular Weight: 304.271
• Mol File: 36244-10-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4(3H)-Quinazolinone, 3-(4-methylphenyl)-2-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 3-(4-methylphenyl)-2-(trifluoromethyl)-(36244-10-7)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 3-(4-methylphenyl)-2-(trifluoromethyl)-(36244-10-7)

Safety Data

• Hazardous Substances Data: 36244-10-7(Hazardous Substances Data)

Upstream product

• 32212-29-6 2-amino-N-ethylbenzamide 
• 126855-72-9 N-(4-methylphenyl)-2,2,2-trifluoroacetimidoyl chloride 
• 4141-08-6 2-Amino-N-methylbenzamid 
• 5471-20-5 2-amino-N-benzylbenzamide 
• 28144-70-9 anthranilic acid amide 
• 99-99-0 1-methyl-4-nitrobenzene 
• 1160967-80-5 2,2,2-trifluoro-N-(2-iodophenyl)acetimidoyl chloride 
• 13939-06-5 molybdenum hexacarbonyl 
• 615-43-0 2-iodophenylamine 
• 106-49-0 p-toluidine 
• 91-56-5 indole-2,3-dione 
• 407-25-0 trifluoroacetic anhydride 

Relevant articles and documents

Palladium-catalyzed synthesis of novel trifluoromethylated quinazolinone, N-arylquinazoline and N-benzylquinazoline derivatives

A simple and palladium-catalyzed procedure for synthesis of a novel series of potentially biologically active trifluoromethyl-substituted quinazolinones and N-arylquinazoline derivatives via condensation-cyclization reaction of 2-aminobenzamide, 2-amino-N′-arylbenzimidamides and 2-amino-N′-benzylbenzimidamides with trifluoroacetimidoyl chlorides has been developed. noteworthy, this investigation showed the possible of transition-metal-catalyzed activation of trifluoroacetimidoyl chlorides as a carbon trifluoromethylated source for the synthesis of quinazolines and quinazolinone derivatives in good to excellent yields.

Method for synthesizing 2-trifluoromethyl substituted quinazolinone by multi-component one-pot method

The invention discloses a method for synthesizing 2-trifluoromethyl substituted quinazolinone by a multi-component one-pot method, and the method comprises the following steps: adding a palladium catalyst, a ligand, a carbon monoxide substitute, an additi

FeCl3-Mediated Synthesis of 2-(Trifluoromethyl)quinazolin-4(3 H)-ones from Isatins and Trifluoroacetimidoyl Chlorides

An FeCl3-mediated cascade coupling/decarbonylative annulation reaction for the efficient construction of 2-(trifluoromethyl)quinazolin-4(3H)-ones has been developed. This transformation employs readily available isatins and trifluoroacetimidoyl chlorides as the starting materials, providing a facile and practical route to diverse biologically relevant quinazolin-4(3H)-one derivatives. A plausible reaction pathway has been proposed based on the mechanistic observations.