36244-10-7

Upstream product

• 99-99-0 1-methyl-4-nitrobenzene 
• 615-43-0 2-iodophenylamine 
• 407-25-0 trifluoroacetic anhydride 
• 126855-72-9 N-(4-methylphenyl)-2,2,2-trifluoroacetimidoyl chloride 
• 91-56-5 indole-2,3-dione 
• 106-49-0 p-toluidine 
• 1160967-80-5 2,2,2-trifluoro-N-(2-iodophenyl)acetimidoyl chloride 
• 13939-06-5 molybdenum hexacarbonyl 
• 28144-70-9 anthranilic acid amide 
• 5471-20-5 2-amino-N-benzylbenzamide 
• 4141-08-6 2-Amino-N-methylbenzamid 
• 32212-29-6 2-amino-N-ethylbenzamide 

Relevant academic research and scientific papers

Palladium-catalyzed synthesis of novel trifluoromethylated quinazolinone, N-arylquinazoline and N-benzylquinazoline derivatives

A simple and palladium-catalyzed procedure for synthesis of a novel series of potentially biologically active trifluoromethyl-substituted quinazolinones and N-arylquinazoline derivatives via condensation-cyclization reaction of 2-aminobenzamide, 2-amino-N′-arylbenzimidamides and 2-amino-N′-benzylbenzimidamides with trifluoroacetimidoyl chlorides has been developed. noteworthy, this investigation showed the possible of transition-metal-catalyzed activation of trifluoroacetimidoyl chlorides as a carbon trifluoromethylated source for the synthesis of quinazolines and quinazolinone derivatives in good to excellent yields.

Method for synthesizing 2-trifluoromethyl substituted quinazolinone by multi-component one-pot method

The invention discloses a method for synthesizing 2-trifluoromethyl substituted quinazolinone by a multi-component one-pot method, and the method comprises the following steps: adding a palladium catalyst, a ligand, a carbon monoxide substitute, an additi

Palladium-Catalyzed Carbonylative Synthesis of 2-(Trifluoromethyl)quinazolin-4(3H)-ones from Trifluoroacetimidoyl Chlorides and Nitro Compounds

A procedure on palladium-catalyzed carbonylative reaction of trifluoroacetimidoyl chlorides and nitro compounds for the construction of pharmaceutically valuable 2-(trifluoromethyl)quinazolin-4(3H)-ones has been achieved. In this transformation, Mo(CO)6 has been used both as a convenient CO source and a reducing reagent. This newly developed protocol is compatible with various nitro compounds and can be readily scaled up to 1 mmol scale. (Figure presented.).

Preparation method of 2 - trifluoromethyl substituted quinazoline ketone compound (by machine translation)

The invention discloses a preparation method of 2 -trifluoromethyl-substituted quinazolone compounds, which comprises the following steps: ferric trichloride and sodium hydrogen. The molecular sieve, trifluoroethyl imine acyl chloride and indirubin were a

FeCl3-Mediated Synthesis of 2-(Trifluoromethyl)quinazolin-4(3 H)-ones from Isatins and Trifluoroacetimidoyl Chlorides

An FeCl3-mediated cascade coupling/decarbonylative annulation reaction for the efficient construction of 2-(trifluoromethyl)quinazolin-4(3H)-ones has been developed. This transformation employs readily available isatins and trifluoroacetimidoyl chlorides as the starting materials, providing a facile and practical route to diverse biologically relevant quinazolin-4(3H)-one derivatives. A plausible reaction pathway has been proposed based on the mechanistic observations.

Palladium-catalyzed four-component carbonylative synthesis of 2,3-disubstituted quinazolin-4(3H)-ones: Convenient methaqualone preparation

A palladium-catalyzed four-component carbonylative cyclization reaction for the synthesis of 2,3-disubstituted quinazolin-4(3H)-ones has been developed. A range of different 2,3-disubstituted quinazolin-4(3H)-one derivatives were prepared in moderate to good yields employing simple and readily accessible 2-iodoanilines, nitro compounds and acid anhydrides as the synthetic precursors. Mo(CO)6 acted both as a solid CO source and a reductant. Notably, methaqualone as a sedative and hypnotic medication can be prepared easily in 68% yield (4b) under our conditions as well.

N,N'-Disubstituted trifluoroacetamidines for trifluoromethylated polynitrogen heterocycles

N,N'-Disubstituted trifluoroacetamidines have been prepared and transformed to the trifluoromethylated polynitrogen heterocycles.