362470-32-4

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 362470-30-2 (+/-)-3-benzyloxy-4,4-dimethylpyrrolidin-2-one 
• 117895-47-3 3-(benzyloxy)-4,4-dimethyldihydrofuran-2(3H)-one 

Downstream Products

• 362470-63-1 (S)-2-(3-Benzoyl-phenyl)-propionic acid (S)-1-carbamoylmethyl-4,4-dimethyl-2-oxo-pyrrolidin-3-yl ester 
• 362470-66-4 (S)-1-carbamoylmethyl-4,4-dimethyl-2-oxopyrrolidinyl (S)-2-(4-isobutylphenyl)propionate 

Relevant academic research and scientific papers

Synthesis of a new insoluble polymer-supported chiral alcohol auxiliary and its first application to nucleophilic addition to ketenes

The preparation of a new optically active alcohol with a carboxylic function that allowed its attachment to an amine-functionalized insoluble polymer is described. Its first use as a polymer supported chiral auxiliary is demonstrated by asymmetric transformation of two racemic aryl propionic acids via ketene formation (95-96% ee).