117895-47-3Relevant academic research and scientific papers
Convergent access to bis-spiroacetals through a sila-Stetter-ketalization cascade
Labarre-Laine, Jessica,Beniazza, Redouane,Desvergnes, Valerie,Landais, Yannick
supporting information, p. 4706 - 4709 (2013/10/08)
An NHC-catalyzed sila-Stetter reaction between aliphatic acylsilanes and vinylketones bearing silyl ether substituents affords functionalized 1,4-diketones, which upon treatment under acidic conditions leads to the corresponding bis-spiroacetals. The two-step sequence may also be carried out in a one-pot operation leading to high yields of the desired bis-spiroacetals.
Enantiodivergent syntheses of pantolactone and pantothenic acid from d -mannitol
Sanyal, Ishita,Barman, Piyalideb,Banerjee, Asishkumar
, p. 1102 - 1108 (2012/05/04)
Efficient synthetic routes to both the enantiomers of pantolactone and pantothenic acid have been developed starting from d-mannitol-based d-glyceraldehyde acetonide through its conversion into a protected pantoic acid intermediate followed by either cyclization or amide bond formation with a -amino ester, and subsequent appropriate deprotection. Georg Thieme Verlag Stuttgart . New York.
HIV INTEGRASE INHIBITORS
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Page/Page column 38, (2010/01/12)
Tricyclic compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein G, T, R1, R2, R3A, R3B, R4A, R4B, R5A, R5B, R6A and R6B are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
Anionic ring-contraction reaction of cyclic acetal system: Stereoselective approach to multi-functionalized oxetanes
Suzuki, Masaki,Tomooka, Katsuhiko
, p. 651 - 654 (2007/10/03)
The reaction of pantolactone derived bicyclic acetal 1 with alkyl lithiums provides 2,2,4-trisubstituted 3-hydroxy oxetane 2 with high diastereoselectivity.
Toward Diels-Alder reactions on a solid support using polymer bound N-substituted 3-hydroxy-4,4-dimethyl-2-pyrrolidinone acrylate derivatives
Akkari, Rhalid,Calmes, Monique,Martinez, Jean
, p. 2441 - 2450 (2007/10/03)
Several N-substituted 3-hydroxy-4,4-dimethyl-2-pyrrolidinone acrylate derivatives, selected to allow their attachment to a polymer, have been prepared and tested as dienophiles in the Diels-Alder reaction. The experiments, performed under TiCl4 catalysis in solution or the solid phase with isoprene and cyclopentadiene as dienes, pointed out the difficulties associated with some of these compounds that failed to give the corresponding cycloadduct. 13C NMR studies provided some evidence regarding the nature of the interactions between the acrylate compounds and TiCl4. It appears that the outcome of the reaction is dependent on the acrylate structure and that the 4-(3-hydroxy-4,4-dimethyl-2-oxopyrrolidin-1-yl)benzoic acid acrylate derivatives are highly efficient to give the cycloadduct in good yield and with high regio- or endoselectivity in both solution and solid-phase reaction conditions. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
Cesium promoted O-alkylation of alcohols for the efficient ether synthesis
Dueno,Chu,Kim,Kyung Woon Jung
, p. 1843 - 1846 (2007/10/03)
Efficient Williamson type O-alkylation of alcohols was developed using cesium bases in the presence of tetrabutylammonium iodide (TBAI) and molecular sieves. Various substrates including unreactive primary and secondary alcohols were converted smoothly to
