36265-54-0

Usage

Uses

Used in Pharmaceutical Research:
1,2-BIS-(4-METHOXY-PHENYL)-ETHYLAMINE is used as a building block in the synthesis of various biologically active compounds. Its versatile structure allows for the development of new drugs with potential therapeutic benefits.
Used in Organic Synthesis:
1,2-BIS-(4-METHOXY-PHENYL)-ETHYLAMINE is utilized as an intermediate in the preparation of complex organic molecules. Its reactivity and functional groups make it a valuable component in the synthesis of a wide range of chemical products.
Used in Medical Research:
1,2-BIS-(4-METHOXY-PHENYL)-ETHYLAMINE is studied for its potential pharmacological activities. It has been identified as a selective serotonin reuptake inhibitor, which suggests its use in the treatment of conditions related to serotonin imbalances, such as depression and anxiety.
Used in Drug Development:
As a novel therapeutic agent, 1,2-BIS-(4-METHOXY-PHENYL)-ETHYLAMINE is being investigated for its potential applications in the medical field. Ongoing research aims to uncover its full range of pharmacological properties and to develop it into a viable treatment option for various health conditions.

InChI:InChI=1/C16H19NO2/c1-18-14-7-3-12(4-8-14)11-16(17)13-5-9-15(19-2)10-6-13/h3-10,16H,11,17H2,1-2H3

Upstream product

• 120-44-5 1,4-di(4-methoxyphenyl)ethanone 
• 540-69-2 ammonium formate 
• 119-52-8 4,4'-dimethoxybenzoin 
• 123-11-5 4-methoxy-benzaldehyde 
• 4705-34-4 4,4'-dimethoxystilbene 
• 5471-45-4 desanisoin oxime 

Downstream Products

• 129060-71-5 α'-amino-bibenzyl-4,4'-diol 
• 135192-19-7 cis-Pt(NH3)Cl2(1,2-bis(4-methoxyphenyl)ethylamine) 
• 135192-19-7 trans-Pt(NH₃)Cl₂(1,2-bis(4-methoxyphenyl)ethylamine) 

Relevant academic research and scientific papers

Substituted (1,2-Diarylethyl)amide Acyl-CoA:Cholesterol Acyltransferase Inhibitors: Effect of Polar Groups on in Vitro and in Vivo Activity

Substituted (1,2-diarylethyl)amides have been prepared and evaluated for their ability to inhibit microsomal acyl-CoA:cholesterol acyltransferase activity in vitro and to lower hepatic cholesteryl ester content in vivo in a cholesterol-fed hamster.Simple unsubstituted (diarylethyl)amides were potent inhibitors in vitro but showed poor activity in vivo.Introduction of polar groups at specific locations on the diarylethylamine moiety decreased in vitro activity but increased in vivo activity.Both effects were highly structure dependent, suggesting specific interactions which were mediating activity in each model.Optimization of these opposing effects led to compounds which were potent in both models.

Regiochemistry on Photoamination of Stilbene Derivatives with Ammonia via Electron Transfer

The regiochemistry of photoamination of 1,2-diarylethene (1) with ammonia in the presence of p-dicyanobenzene (DCNB) has been investigated.The photoamination of stilbene and p,p'-dimethoxystilbene gave 1-amino-1,2-diphenylethane and 1-amino-1,2-bis(p-methoxyphenyl)ethane, respectively.The photoamination of unsymmetric 1-aryl-2-phenylethene having an alkoxy group on the para position occurred selectively to give 1-amino-2-aryl-1-phenylethane.On the other hand, the photoamination of 1-aryl-2-phenylethene having a methyl and chloro group on the para position or methoxy group on the meta and ortho positions gave both 1-amino-2-aryl-1-phenylethane and 1-amino-1-aryl-2-phenylethane.The regiochemistry is related with the distribution of positive charge in the cation radicals of 1 generated from photochemical electron transfer to DCNB.