36268-67-4

Basic information

• Product Name: 4-(METHANESULFONYLAMINO)BENZONITRILE
• Synonyms: 4-(METHANESULFONYLAMINO)BENZONITRILE;4-(Methanesulfonylamino)benzonitrile,97%;4-(METHYLSULFONYLAMINO)BENZONITRILE;4-(Methanesulfonylamino)benzonitrile,98%
• CAS NO: 36268-67-4
• Molecular Formula: C₈H₈N₂O₂S
• Molecular Weight: 196.23
• Product Categories: Boron, Nitrile, Thio,& TM-Cpds
• Mol File: 36268-67-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: 191-194 °C
• Boiling Point: 365.5 °C at 760 mmHg
• Flash Point: 174.8 °C
• Appearance: beige fine crystalline powder
• Density: 1.36 g/cm³
• Vapor Pressure: 1.57E-05mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(METHANESULFONYLAMINO)BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(METHANESULFONYLAMINO)BENZONITRILE(36268-67-4)
• EPA Substance Registry System: 4-(METHANESULFONYLAMINO)BENZONITRILE(36268-67-4)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 37/39-36/37
• RIDADR: 3276
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 36268-67-4(Hazardous Substances Data)

Usage

Chemical Properties

beige fine crystalline powder

InChI:InChI=1/C8H8N2O2S/c1-13(11,12)10-8-4-2-7(6-9)3-5-8/h2-5,10H,1H3

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 873-74-5 4-Aminobenzonitrile 
• 7143-01-3 Methanesulfonic anhydride 
• 3144-09-0 methanesulfonamide 
• 623-00-7 4-bromobenzenecarbonitrile 
• 619-72-7 4-nitrobenzonitrile 

Downstream Products

• 106307-03-3 2-methoxyethyl 4-mesylaminobenzimidate hydrochloride 
• 4714-65-2 N-butyl-4-aminobenzonitrile 
• 401909-80-6 N-(4-cyano-2-nitrophenyl)methanesulfonamide 
• 128263-66-1 N-<4-(aminomethyl)phenyl>methanesulfonamide hydrochloride 
• 106307-13-5 N-(3-dimethylaminopropyl)-2-(4-mesylamino)-5⁽⁶⁾-benzimidazolecarboxamide hydrochloride 
• 148459-01-2 4-((methylsulfonyl)amino)benzenecarboxamide oxime 

Relevant articles and documents

1,2,4-oxadiazol derivatives compound and antiviral agent containing the same as an active ingredient

1, 2, 4 - Oxadiazole derivative compounds and antiviral agents containing the same as an active ingredient. The compound has antiviral activity without cytotoxicity and has antiviral activity, and thus can be useful as an antiviral agent.

Continuous-Flow Electrosynthesis of Benzofused S-Heterocycles by Dehydrogenative C?S Cross-Coupling

Reported herein is the synthesis of benzofused six-membered S-heterocycles by intramolecular dehydrogenative C?S coupling using a modular flow electrolysis cell. The continuous-flow electrosynthesis not only ensures efficient product formation, but also obviates the need for transition-metal catalysts, oxidizing reagents, and supporting electrolytes. Reaction scale-up is conveniently achieved through extended electrolysis without changing the reaction conditions and equipment.

Soft-Hard Acid/Base-Controlled, Oxidative, N-Selective Arylation of Sulfonanilides via a Nitrenium Ion

In iodine(III)-catalyzed, dehydrogenative arylations of sulfonanilides, the functionalization of C-C bonds is preferred over the functionalization of C-N bonds. Herein, an unprecedented N-selective arylation of sulfonanilides using soft-hard acid-base (SHAB) control by a nitrenium ion over a carbenium ion is reported. Treatment of sulfonanilides with iodine(III) led to the formation of nitrenium ions (soft), which preferentially react with biphenyls (soft) over bimesityl (hard) to generate C-N bonds. The iodine(III) was generated in situ by using PhI and mCPBA at room temperature.