36295-63-3

Upstream product

• 1032-02-6 diethyl 2-(benzyl(methyl)amino)propanedioate 
• 685-87-0 Diethyl 2-bromomalonate 
• 105-53-3 diethyl malonate 
• 74-89-5 methylamine 

Downstream Products

• 63931-29-3 2-[(5-Methoxy-2-nitro-benzoyl)-methyl-amino]-malonic acid diethyl ester 
• 63931-28-2 2-[(5-Chloro-2-nitro-benzoyl)-methyl-amino]-malonic acid diethyl ester 
• 63931-26-0 2-[(4-Chloro-2-nitro-benzoyl)-methyl-amino]-malonic acid diethyl ester 
• 865879-16-9 ethyl N-[N-benzyloxycarbonylsarcosyl]-2-ethoxycarbonylsarcosinate 
• 1344700-32-8 1-(4-cyclopropylbuta-1,3-diyn-1-yl)-4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}benzene 
• 1344700-43-1 1-(dimethoxymethyl)-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene 
• 1344700-44-2 1-formyl-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene 
• 1344700-45-3 1-[(cyclopropylamino)methyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene 
• 1344700-55-5 1-[1-(cyclopropylamino)ethyl]-4-[(4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}phenyl)ethynyl]benzene 
• 1344700-02-2 1-iodo-4-{[1-methoxy-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamoyl}benzene 

Relevant academic research and scientific papers

SPIRO-LACTAM NMDA MODULATORS AND METHODS OF USING SAME

Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

Synthesis of some new 5-dialkylaminomethylhydantoins and related compounds

In this paper, we describe the synthesis of new 5-dialkylaminomethyl- substituted hydantoin derivatives (3 and 9) from β-aminoalanines (1 or 6) and some chemical properties of the synthesized compounds. A synthetic trial for the preparation of a new twin-

The synthetic versatility of alkoxycarbonyl- and hydroxymethyl-piperazine- 2,5-diones

Alkoxycarbonylpiperazine-2,5-diones are versatile precursors for the α-functionalisation of piperazine-2,5-diones. The alkoxycarbonyl group activates the α-carbon position to alkylation reactions and this provides a mild and selective method for the extension of the carbon framework of piperazine-2,5-diones. In addition, the alkoxycarbonyl group can be converted to the carboxy group, which in turn can be 'deleted' or manipulated for the installation of carbon and/or heteroatom substituents where desired, the latter via N-acyliminium chemistry. We also demonstrate that hydroxymethylpiperazine-2, 5-diones complement carboxypiperazinediones as precursors for the generation of N-acyliminium ions.

ORGANIC PHOSPHORUS COMPOUNDS 76 SYNTHESIS AND PROPERTIES OF PHOSPHINOTHRICIN DERIVATIVES

The synthesis, chemical and spectral properties of phosphinothricin analogues which either have other groups than methyl attached to phosphorus (30 to 40) or bear substituents on nitrogen (43 to 50) are described and the activity of some of these derivatives as glutamine synthetase inhibitors and contact herbicides is reported.