(Methylamino)malonic acid diethyl ester

Base Information

• Chemical Name: (Methylamino)malonic acid diethyl ester
• CAS No.: 36295-63-3
• Molecular Formula: C8H15NO4
• Molecular Weight: 189.20900
• Hs Code.: 2922499990
• Mol file: 36295-63-3.mol

Synonyms:methylamino-malonic acid diethyl ester;Methylamino-malonsaeure-diaethylester;diethyl (methylamino)malonate;diethyl N-methylaminomalonate;diethyl (methylamino)propanedioate;diethyl N-methyl-2-aminomalonate;Propanedioic acid,(methylamino)-,diethyl ester;

Chemical Property of (Methylamino)malonic acid diethyl ester

Chemical Property:

• PSA: 64.63000
• LogP: 0.09150

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Methylamino)malonic acid diethyl ester

There total 5 articles about (Methylamino)malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

diethyl 2-(benzyl(methyl)amino)propanedioate (1032-02-6) → diethyl 2-(methylamino)propanedioate (36295-63-3)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1016/j.tet.2005.06.084

Reference yield: 86.0%

Diethyl 2-bromomalonate (685-87-0) + methylamine (74-89-5) → diethyl 2-(methylamino)propanedioate (36295-63-3)

Guidance literature:

In ethanol; at 20 ℃; for 15h;

Reference yield:

Diethyl 2-bromomalonate (685-87-0) → diethyl 2-(methylamino)propanedioate (36295-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: H₂ / PtO₂ / acetic acid

With hydrogen; platinum(IV) oxide; In ethanol; acetic acid;

upstream raw materials:

diethyl 2-(benzyl(methyl)amino)propanedioate

Diethyl 2-bromomalonate

methylamine

diethyl malonate

Downstream raw materials:

2-[(5-Methoxy-2-nitro-benzoyl)-methyl-amino]-malonic acid diethyl ester

2-[(5-Chloro-2-nitro-benzoyl)-methyl-amino]-malonic acid diethyl ester

2-[(4-Chloro-2-nitro-benzoyl)-methyl-amino]-malonic acid diethyl ester

ethyl N-[N-benzyloxycarbonylsarcosyl]-2-ethoxycarbonylsarcosinate