36405-75-1

Upstream product

• 110-89-4 piperidine 
• 701-99-5 Phenoxyacetyl chloride 
• 2555-49-9 phenoxyacetic acid ethyl ester 
• 122-59-8 2-phenoxyacetic acid 

Downstream Products

• 126026-63-9 phenoxythioacetopiperidide 
• 1198168-53-4 4-oxo-4-[4-(2-oxo-2-piperidin-1-yl-ethoxy)phenyl]butyric acid 
• 1198168-56-7 3-methyl-4-oxo-4-[4-(2-oxo-2-piperidin-1-yl-ethoxy)phenyl]-butyric-acid 
• 2591-86-8 N-Formylpiperidine 
• 104294-19-1 pyridin-2-ylmethoxybenzene 

Relevant academic research and scientific papers

Solvent-free iron(III) chloride-catalyzed direct amidation of esters

Amide functional groups are prominent in a broad range of organic compounds with diverse beneficial applications. In this work, we report the synthesis of these functional groups via an iron(iii) chloride-catalyzed direct amidation of esters. The reactions are conducted under solvent-free conditions and found to be compatible with a range of amine and ester substrates generating the desired amides in short reaction times and good to excellent yields at a catalyst loading of 15 mol%.

Efficient procedure for the preparation of amides using polymer-bound reagents

An effective method for the conversion of acids into amides is presented. The two-step procedure includes the preparation of acid chloride intermediates using Pol-Ph3P and subsequent treatment of these intermediates with amines and polymer-bound base. The amides were accessible in high yields and purities without further purification.