104294-19-1

Upstream product

• 4377-33-7 2-chloromethylpyridine 
• 139-02-6 sodium phenoxide 
• 274-59-9 triazolopyridine 
• 108-95-2 phenol 
• 6959-47-3 2-chloromethylpyridine hydrochloride 
• 109-09-1 2-chloropyridine 
• 36405-75-1 2-phenoxy-1-(piperidin-1-yl)ethanone 
• 31106-82-8 2-(bromomethyl)pyridine hydrobromide 

Downstream Products

• 1448610-49-8 C₁₆H₁₇NO₂ 
• 1448610-50-1 C₁₇H₂₁NO₂ 

Relevant academic research and scientific papers

2-Pyridylmethyl ether: A readily removable and efficient directing group for amino acid ligand accelerated ortho-C-H olefination of phenols

2-Pyridylmethyl ether-directed ortho-C-H olefination of phenols via a seven-membered cyclopalladated intermediate has been disclosed to construct a variety of ortho-alkenyl phenols and ortho-alkyl phenols.

Highly Enantioselective Hydrogenation of Amides via Dynamic Kinetic Resolution Under Low Pressure and Room Temperature

High-throughput screening and lab-scale optimization were combined to develop the catalytic system trans-RuCl2((S,S)-skewphos)((R,R)-dpen), 2-PrONa, and 2-PrOH. This system hydrogenates functionalized α-phenoxy and related amides at room temperature under 4 atm H2 pressure to give chiral alcohols with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.

HETEROCYCLIC COMPOUNDS AS INHIBITORS OF LEUKOTRIENE PRODUCTION

The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R7, A and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes