364340-35-2Relevant academic research and scientific papers
Copper-Catalyzed Three-Component Reactions of 2-Iodo-2,2-difluoroacetophenones, Alkynes, and Trimethylsilyl Cyanide
Wu, Pingjie,Zheng, Cheng,Wang, Xia,Wu, Jingjing,Wu, Fanhong
, p. 1420 - 1423 (2021)
A Cu(I)-catalyzed three-component reaction of 2-iodo-2,2-difluoroacetophenones, alkynes, and TMSCN is described. The reaction provided a facile method for the synthesis of difluoroacyl-substituted nitriles, which might be served as potentially useful fluo
Nickel-Catalyzed Coupling Reaction of α-Bromo-α-fluoroketones with Arylboronic Acids toward the Synthesis of α-Fluoroketones
Liang, Junqing,Han, Jie,Wu, Jingjing,Wu, Pingjie,Hu, Jian,Hu, Feng,Wu, Fanhong
supporting information, p. 6844 - 6849 (2019/09/07)
A nickel-catalyzed coupling reaction of α-bromo-α-fluoroketones with arylboronic acids was reported, which provides an efficient pathway to access 2-fluoro-1,2-diarylethanones in high yields. We also disclosed the synthesis of the monofluorination agents
Detrifluoroacetylation Reaction of Trifluoromethyl-β-diketones: Facile Method for the Synthesis of Succinimide Derivatives and 1,4-Diketones
Wang, Li-Hua,Zhao, Jing
supporting information, p. 4345 - 4348 (2018/08/31)
Currently, a great deal of research efforts are focused on C–C bond activation for development of novel synthetic methodology. In this paper, a detrifluoroacetylation of trifluoromethyl-β-diketones is described, which allows for the synthesis of succinimides and 1,4-diketones through cascade Michael addition/retro-Claisen reaction and nucleophilic substitution/retro-Claisen reaction. The readily available trifluoromethyl-β-diketones, wide substrate scope, and mild conditions make this method very practical.
Synthesis of α,α-difluorobenzoyl oxygen heterocycles via the radical reaction of 2-iodo-2,2-difluoroacetophenones with unsaturated acids or unsaturated alcohols
Chen, Heng,Wang, Jiexiong,Wu, Jingjing,Kuang, Yujia,Wu, Fanhong
, p. 41 - 46 (2017/06/14)
A convenient and facile method for the direct synthesis of α,α-difluorobenzoyl lactones or cyclic ethers via the radical cyclization reaction of 2-iodo-2,2-difluoroacetophenone with unsaturated acids or alcohols was reported.
Highly enantioselective construction of 3-hydroxy oxindoles through a decarboxylative aldol addition of trifluoromethyl α-fluorinated gem-diols to n-benzyl isatins
Saidalimu, Ibrayim,Fang, Xiang,He, Xiao-Peng,Liang, Jing,Yang, Xueyan,Wu, Fanhong
supporting information, p. 5566 - 5570 (2013/06/27)
An organocatalytic asymmetric direct aldol addition reaction that involves cleavage of a carbon-carbon bond through the release of trifluoroacetate was developed. The protocol is wide in scope, generating the desired oxindoles of biological interest in nearly quantitative yields (up to 99 %) with excellent enantioselectivities (up to 98 % ee) and diastereoselectivities (up to 99:1 d.r.). Copyright
