3652-61-7

Usage

Uses

Used in Organic Synthesis:
ETHYL 2-METHYL-1,5-DIPHENYLPYRROLE-3-CARBOXYLATE is used as a building block in organic synthesis for the creation of various biologically active molecules.
Used in Pharmaceutical Research:
In pharmaceutical research, ETHYL 2-METHYL-1,5-DIPHENYLPYRROLE-3-CARBOXYLATE is utilized as a key component in the development of new drugs.
Used in Antimicrobial Applications:
ETHYL 2-METHYL-1,5-DIPHENYLPYRROLE-3-CARBOXYLATE has been studied for its potential antimicrobial properties, making it a candidate for use in applications targeting the inhibition of microbial growth.
Used in Anticancer Applications:
ETHYL 2-METHYL-1,5-DIPHENYLPYRROLE-3-CARBOXYLATE has also been investigated for its potential anticancer properties, indicating its possible use in cancer treatment and research.

InChI:InChI=1/C20H19NO2/c1-3-23-20(22)18-14-19(16-10-6-4-7-11-16)21(15(18)2)17-12-8-5-9-13-17/h4-14H,3H2,1-2H3

Upstream product

• 109662-95-5 1-(2-amino-phenyl)-2-methyl-5-phenyl-pyrrole-3-carboxylic acid ethyl ester 
• 52313-46-9 ethyl 2-acetyl-4-oxo-4-phenylbutanoate 
• 75-52-5 nitromethane 
• 141-97-9 ethyl acetoacetate 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 
• 100-42-5 styrene 
• 6287-35-0 ethyl 3-anilinocrotonate 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 
• 57957-24-1 N-(1-phenylvinyl)acetamide 
• 6287-35-0 3-phenylaminobut-2-enoic acid ethyl ester 
• 536-74-3 phenylacetylene 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 130850-59-8 4-Bromo-2-methyl-1,5-diphenyl-1H-pyrrole-3-carboxylic acid 
• 130850-61-2 4-Bromo-2-methyl-1,5-diphenyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 109812-64-8 2-methyl-1,5-diphenyl-pyrrole-3-carboxylic acid 

Relevant academic research and scientific papers

Novel and highly efficient preparation of pyrroles using supported ionic liquid ILCF3SO3@SiO2 as a heterogeneous catalyst

Abstract: A supported ionic liquid ILCF3SO3@SiO2 was synthesized and used as a highly efficient catalyst in the Paal–Knorr reaction for the preparation of pyrroles. The heterogeneous catalyst could be easily recovered and recycled for five times without noticeable loss of catalytic activity. Also a possible reaction mechanism is provided.

Microwave radiation one-step synthesis of substituted pyrrole-3-carboxylic acid ester compound method

The invention discloses a method for synthesizing a substituted pyrrole-3-formate compound by virtue of microwave radiation in one step, and relates to a synthetic method of the substituted pyrrole-3-formate compound. The method disclosed by the invention

Microwave-assisted one pot synthesis of N-substitued 2-methyl-1H-pyrrole-3-carboxylate derivatives without catalyst and solvent

An efficient one-pot synthetic method for the N-substituted 2-methyl-1H-pyrrole-3-carboxylate derivatives has been accomplished via a microwave irradiation MCRs of various α-bromoacetophenone, amines, and ethyl acetoacetate without any solvent and catalys

Copper-mediated cross-coupling-cyclization-oxidation: A one-pot reaction to construct polysubstituted pyrroles

A novel and efficient procedure for the synthesis of polysubstituted pyrroles has been developed in this work. The polysubsituted pyrroles were synthesized directly from terminal alkenes, amines and β-keto esters through cross-coupling-cyclization-oxidation in the presence of a catalytic amount of cuprous chloride. This method provides a one-pot synthesis route from terminal alkenes to polysubstituted pyrroles for the first time and opens a new area in cuprous catalysis. The Royal Society of Chemistry 2014.

Direct oxidative coupling of enamides and 1,3-dicarbonyl compounds: A facile and versatile approach to dihydrofurans, furans, pyrroles, and dicarbonyl enamides

An efficient manganese(III)-mediated oxidative coupling reaction between α-aryl enamides and 1,3-dicarbonyl compounds has been developed. A series of dihydrofurans and dicarbonyl enamides were synthesized in moderate to good yields. Moreover, these dihydrofurans could be readily transformed into the corresponding furans and pyrroles via the Paal-Knorr reaction.

One-pot four-component synthesis of highly substituted pyrroles in gluconic acid aqueous solution

Four-component coupling of amines, aldehydes, 1,3-dicarbonyl compounds, and nitromethane has been achieved in gluconic acid aqueous solution (GAAS) to produce polysubstituted pyrroles in high yield. Gluconic acid aqueous solution could be recycled and reu

Silver-mediated oxidative C-H/C-H functionalization: A strategy to construct polysubstituted furans

A novel silver-mediated highly selective oxidative C-H/C-H functionalization of 1,3-dicarbonyl compounds with terminal alkynes for the creation of polysubstituted furans and pyrroles in one step has been demonstrated. Promoted by the crucial silver specie

An efficient procedure for the synthesis of polysubstituted pyrroles in an ionic liquid

The ionic liquid 1-butyl-3-methyl-imidazolium hydrogen sulfate, [bmim]HSO4, was used as a catalyst and reaction medium for the pyrrole synthesis, and a wide range of aliphatic, aromatic, heteroaromatic and carboxylic 1,4-diketones easily underwent condensations with aniline and ethylenediamine to form polysubstituted pyrroles. Sequential decarboxylation/Paal-Knorr pyrrole condensation was observed, which provides a new and facile approach to monoester pyrroles from 1,4-diketo-2,3-dicarboxylic acid esters.

N-substituted pyrrole synthesis by Paal-Knorr condensation using recyclable cationic exchange resin in water

(Chemical Equation Presented) Cationic exchange resin has been utilized for the first time as a novel and recyclable heterogeneous catalyst for the synthesis of N-substituted pyrroles from variety of 1,4-diketones and aniline. This simple synthesis has been accomplished with excellent yields. The recovered catalyst can be reused for subsequent runs with only a gradual decrease in activity.

1,5-DIARYL-PYRROLE-3-CARBOXAMIDE DERIVATIVES AND THEIR USE AS CANNABINOID RECEPTOR MODULATORS

The present invention relates to a compound of formula (I) (A chemical formula should be inserted here - please see paper copy enclosed herewith) in which R1 and R2 independently represent phenyl, thienyl or pyridyl each of which is