3655-88-7Relevant academic research and scientific papers
Design and synthesis of novel 2-(6-thioxo-1,3,5-thiadiazinan-3-yl)-N′-phenylacethydrazide derivatives as potential fungicides
Wang, Xiaobin,Fu, Xincan,Yan, Jinghua,Wang, An,Wang, Mengqi,Chen, Min,Yang, Chunlong,Song, Yimin
, p. 573 - 583 (2019)
A series of novel 2-(6-thioxo-1,3,5-thiadiazinan-3-yl)-N′-phenylacethydrazide derivatives were designed, synthesized and evaluated for their antifungal activities against Fusarium graminearum (Fg), Rhizoctonia solani (Rs), Botrytis cinerea (Bc) and Collet
New prodrug approach for amino acids and amino-acid-like drugs
Aboul-Fadl,El-Shorbagi
, p. 165 - 169 (2007/10/03)
A series of disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) derivatives 4a-g were prepared and found to be promising prodrugs for amino acids and similar compounds. The pH profile for the degradation of the THTT derivatives in aqueous buffer solutions was determined using HPLC and was accounted for in terms of specific base-catalyzed reactions. The compounds, however, showed high acid stability. Enzymatic hydrolysis (human serum) of the derivatives offered an advantageous range of t( 1/2 ) values, which may be useful in controlling the onset and the duration of action of drugs.
