36638-50-3Relevant academic research and scientific papers
Synthesis of α-phenylselanyl and α-phenylsulfanyl nitriles from aldehyde N,N-dialkylhydrazones
Ternon, Micha?l,Pannecoucke, Xavier,Outurquin, Francis,Paulmier, Claude
, p. 3275 - 3279 (2002)
Phenylselenenylation of azaenolates, formed by LDA treatment of dimethylhydrazones 1 (R2=H) and derived from linear aliphatic aldehydes, has led to α-phenylselanyl hydrazones 2. α-Phenylselanyl nitriles 3 were, however, isolated when an excess of base and of PhSeX (X=Cl, Br) were used. Hydrazones 1 bearing an α-alkyl substituent (R2≠H) gave also nitriles 3. SAMP-hydrazones 4 showed the same reactivity and the corresponding nitriles 3 were obtained in a racemic form. The use of PhSCl, in the place of PhSeBr, has led to α-phenylsulfanyl nitriles 6 from hydrazones 1 derived from α-branched aldehydes (R2≠H).
Synthesis of α-Phenylthio Alkyl Nitriles from α-Chloro Alkyl Phenyl Sulfides
Fortes, Carlos C.,Okino, Esmeralda A.
, p. 1943 - 1948 (2007/10/02)
α-Chloro alkyl phenyl sulfides are converted with trimethylsilyl cyanide, in a reaction catalyzed by SnCl4, into α-phenylthio alkyl nitriles.
