36639-50-6

Usage

Uses

Used in Pharmaceutical Industry:
4-Nitrobenzenemethanesulfonic acid sodium salt is used as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and medicines. Its role in this industry is pivotal for creating a range of therapeutic agents.
Used in Dye Industry:
In the dye industry, 4-Nitrobenzenemethanesulfonic acid sodium salt is utilized as an intermediate for the production of dyes. Its chemical properties make it suitable for creating a variety of colorants used in textiles, printing, and other applications.
Used in Chemical Synthesis:
4-Nitrobenzenemethanesulfonic acid sodium salt is used as a building block in the synthesis of sulfonated aromatics, which are important for the creation of various chemical compounds with specialized uses.
Used in Electroless Plating:
Sodium 4-nitrobenzenesulfonate is employed as a reducing agent in electroless plating processes. Its reducing capabilities are essential for the deposition of metals on various substrates without the need for external electrical power.
Used in Water Treatment:
4-Nitrobenzenemethanesulfonic acid sodium salt is used as a corrosion inhibitor in water treatment applications. Its ability to prevent corrosion makes it a valuable component in formulations that protect infrastructure and equipment from deterioration due to water exposure.

Upstream product

• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 100-14-1 4-nitrobenzyl chloride 

Downstream Products

• 4025-75-6 (4-nitrophenyl)methanesulfonyl chloride 
• 1064656-82-1 1-benzyl-3-(4-nitrophenyl)-3,4-dihydro-1H-2,1-benzothiazin-4-one 2,2-dioxide 
• 6387-28-6 (4-aminophenyl)methanesulfonic acid 
• 88918-88-1 4-Amino-N,N-dimethylbenzenemethanesulphonamide 
• 88918-70-1 N,N-dimethyl-4-nitrobenzenemethanesulphonamide 
• 110654-58-5 1,3,5-Tris-(4-nitro-phenylmethanesulfonyl)-[1,3,5]triazinane 
• 110654-61-0 N-Methyl-N-{[methyl-(4-nitro-phenylmethanesulfonyl)-amino]-methyl}-C-(4-nitro-phenyl)-methanesulfonamide 
• 85952-29-0 (4-nitro-phenyl)-methanesulfonic acid methylamide 
• 88918-72-3 4-nitrobenzenemethanesulphonamide 
• 803728-00-9 N,N-bis(2,4-dimethoxybenzyl)-1,1-difluoro-1-(4-nitrophenyl)methanesulfonamide 
• 803727-91-5 N,N-bis(2,4-dimethoxybenzyl)-1-(4-nitrophenyl)methanesulfonamide 

Relevant academic research and scientific papers

Olefination with Sulfonyl Halides and Esters: E-Selective Synthesis of Alkenes from Semistabilized Carbanion Precursors

Carbanions of sulfonyl halides and activated sulfonates add to carbonyl compounds, and so-formed aldol-type adducts spontaneously fragment into olefins. This transformation mimics the one-pot Julia olefination with (hetero)aryl sulfones, but the mechanism of fragmentation involves a four-membered intermediate, typical for reactivity of phosphorus reagents. Moreover, in contrast to the reactions of sulfones, sulfonates of fluorinated alcohols (TFE and HFI) produce byproducts that are easily removed during workup. In our report, we focus on reactions of unstabilized and semistabilized carbanion precursors: alkylsulfonates, and allyl- and benzylsulfonates, respectively. In particular for semistabilized systems, olefins were synthesized as predominant E isomers in good yields. The presented studies reveal that optimal reaction conditions, including the type of base and alcohol groups of the sulfonates, are different depending on stabilization of the carbanion precursors and structure of the carbonyl substrates. The practical synthetic guide is supplemented with a discussion of the mechanism, based on reactivity studies of intermediates and identification of side-products.

Examination of mercaptobenzyl sulfonates as catalysts for native chemical ligation: Application to the assembly of a glycosylated Glucagon-Like Peptide 1 (GLP-1) analogue

3/4-Mercaptobenzyl sulfonates were investigated as aryl thiol catalysts for native chemical ligation (NCL). Whilst catalysing NCL processes at a similar rate to 4-mercaptophenyl acetic acid (MPAA), the increased polarity and solubility of 3-mercaptobenzyl

INDOLYLALKYL DERIVATIVES OF PYRIMIDINYLPIPERAZINE AND METABOLITES THEREOF FOR TREATMENT OF ANXIETY, DEPRESSION, AND SEXUAL DYSFUNCTION

The present invention relates to a method for alleviation, prevention, and treatment of anxiety, depression, and sexual dysfunction by administering certain indolylalkyl derivatives of pyrimidinylpiperazine or metabolites thereof. A preferred embodiment is of the following formula:

PREPARATION AND UTILITY OF SUBSTITUTED INDOLES

Disclosed herein are substituted indoles of Formula I, processes of preparation there of, pharmaceutical compositions thereof, and methods of their use there of.

Synthesis of α-fluorosulfonamides by electrophilic fluorination

(Chemical Equation Presented) α-Fluorosulfonamides were prepared by electrophilic fluorination of tertiary sulfonamides using N- fluorobenzenesulfonimide as fluorinating agent and utilizing the dimethoxybenzyl group (DMB) as a new sulfonamide protecting g

Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkylpiperazines

A series of novel alkoxypyridin-4-yl and alkoxypyrimidin-4-yl derivatives of indol-3-ylalkylpiperazines of Formula I are intended to be useful agents STR1 for alleviation of vascular headache on the basis of their potent affinity and agonist activity at 5-HT1D binding sites.

INDOLYLALKYL DERIVATIVES OF PYRIMIDINYLPIPERAZINE FOR TREATING VASCULAR HEADACHE

A series of novel indol-3-ylalkyl derivatives of alkoxypyrimidinylpiperazines are disclosed as Formula I. STR1 These compounds are intended to be useful agents for alleviation of vascular headache on the basis of their potent affinity and agonist activity at 5-HT1D binding sites.